Escherichia coli Migula (bacterium) K-12 MG1655 [ECO]

FULL NAME: DNA topoisomerase 4 subunit B


DESCRIPTION:
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

STRUCTURE SIMILARITY:
Belongs to the type II topoisomerase family.


PROTEIN TYPE(S):
accessory protein


RELATED PATHWAY(S):
DNA replication
prokaryotic nucleoid remodeling


Amino acids sequence

        10         20         30         40         50         60
MTQTYNADAI EVLTGLEPVR RRPGMYTDTT RPNHLGQEVI DNSVDEALAG HAKRVDVILH
        70         80         90        100        110        120
ADQSLEVIDD GRGMPVDIHP EEGVPAVELI LCRLHAGGKF SNKNYQFSGG LHGVGISVVN
       130        140        150        160        170        180
ALSKRVEVNV RRDGQVYNIA FENGEKVQDL QVVGTCGKRN TGTSVHFWPD ETFFDSPRFS
       190        200        210        220        230        240
VSRLTHVLKA KAVLCPGVEI TFKDEINNTE QRWCYQDGLN DYLAEAVNGL PTLPEKPFIG
       250        260        270        280        290        300
NFAGDTEAVD WALLWLPEGG ELLTESYVNL IPTMQGGTHV NGLRQGLLDA MREFCEYRNI
       310        320        330        340        350        360
LPRGVKLSAE DIWDRCAYVL SVKMQDPQFA GQTKERLSSR QCAAFVSGVV KDAFILWLNQ
       370        380        390        400        410        420
NVQAAELLAE MAISSAQRRM RAAKKVVRKK LTSGPALPGK LADCTAQDLN RTELFLVEGD
       430        440        450        460        470        480
SAGGSAKQAR DREYQAIMPL KGKILNTWEV SSDEVLASQE VHDISVAIGI DPDSDDLSQL
       490        500        510        520        530        540
RYGKICILAD ADSDGLHIAT LLCALFVKHF RALVKHGHVY VALPPLYRID LGKEVYYALT
       550        560        570        580        590        600
EEEKEGVLEQ LKRKKGKPNV QRFKGLGEMN PMQLRETTLD PNTRRLVQLT IDDEDDQRTD
       610        620        630
AMMDMLLAKK RSEDRRNWLQ EKGDMAEIEV   

Encoded by parE gene


OTHER NAME(S):
ECK3021
JW2998
nfxD


DESCRIPTION:
Topo IV is stimulated by SeqA. [More information is available at EcoGene: EG10687]. The crystal structures of two N-terminal fragments of ParE have been solved . [More information is available at EcoCyc: EG10687].


Nucleic acid sequence

        10         20         30         40         50         60
atgacgcaaa cttataacgc tgatgccatt gaggtactca ccgggcttga gccggttcgc
        70         80         90        100        110        120
cgccgtccgg ggatgtatac cgataccact cgccctaacc atttggggca agaagtcatt
       130        140        150        160        170        180
gataacagtg tggatgaagc actggcgggt cacgcaaaac gcgtggacgt tattttacat
       190        200        210        220        230        240
gctgaccagt cgttagaagt tattgacgat gggcgcggga tgccggtgga tattcacccg
       250        260        270        280        290        300
gaagagggtg taccggcggt tgaactgatt ctttgccgtc tgcatgcagg cggtaaattc
       310        320        330        340        350        360
tctaacaaaa attaccagtt ctctggcggc ctgcatggcg tggggatttc ggtggttaac
       370        380        390        400        410        420
gccctgtcga agcgcgtaga agttaacgtg cgccgcgatg gtcaggttta taacatcgcc
       430        440        450        460        470        480
tttgaaaatg gcgaaaaggt gcaggattta caggttgtcg gcacttgcgg taaacgcaat
       490        500        510        520        530        540
actggtacca gtgtgcactt ctggccggat gaaaccttct ttgacagccc gcgattttct
       550        560        570        580        590        600
gtttcacgcc tgacgcatgt gctgaaagcc aaagcggtat tgtgccctgg cgttgagatc
       610        620        630        640        650        660
acttttaaag atgagatcaa caataccgaa caacgctggt gctatcagga cggtctgaat
       670        680        690        700        710        720
gattacctgg cggaagcggt aaatggtctg ccgacgctgc cggaaaaacc gtttatcggt
       730        740        750        760        770        780
aatttcgctg gtgatactga agctgtggac tgggcgctac tgtggctgcc ggaaggcggt
       790        800        810        820        830        840
gaactgctga ccgaaagcta cgtcaacctt atcccaacga tgcagggcgg tacccatgtt
       850        860        870        880        890        900
aatggtctgc gtcagggcct gttggacgcg atgcgtgagt tctgtgaata ccgcaatatt
       910        920        930        940        950        960
ctgccgcgcg gtgtaaagct gtcggcggaa gatatctggg atcgctgcgc ctatgtgctg
       970        980        990       1000       1010       1020
tcagtaaaaa tgcaggatcc gcagtttgcc gggcagacga aagagcgtct ctcttcgcgt
      1030       1040       1050       1060       1070       1080
caatgcgcgg cattcgtttc tggcgtggtg aaagatgcct ttatcctgtg gctgaaccag
      1090       1100       1110       1120       1130       1140
aacgttcagg cggctgaact gctggcggag atggcgattt ccagcgccca gcgccgtatg
      1150       1160       1170       1180       1190       1200
cgtgcggcca aaaaagtggt gcgtaaaaag ctgaccagcg gcccggcgtt gcctggcaaa
      1210       1220       1230       1240       1250       1260
ctggctgatt gtaccgcgca ggaccttaac cgtaccgagc tgttccttgt ggaaggtgac
      1270       1280       1290       1300       1310       1320
tccgcaggcg gatctgccaa gcaggcgcgc gatcgcgaat atcaggcgat catgccactg
      1330       1340       1350       1360       1370       1380
aaaggtaaga tccttaacac ctgggaagtc tcttccgacg aagtgctggc ttcgcaggaa
      1390       1400       1410       1420       1430       1440
gtgcacgata tttcggtagc gatcggtatc gatcctgaca gcgacgatct gagccagctt
      1450       1460       1470       1480       1490       1500
cgttatggca aaatctgtat cctcgcggat gcggactctg atggtctgca cattgccacg
      1510       1520       1530       1540       1550       1560
ctgctctgcg ctttgttcgt aaaacatttc cgcgcgttgg tgaaacacgg tcacgtttac
      1570       1580       1590       1600       1610       1620
gtcgcactgc caccgctcta ccgtattgat ctcgggaaag aggtttatta cgcgctgacg
      1630       1640       1650       1660       1670       1680
gaagaagaga aagagggcgt acttgagcaa ttaaaacgca agaaaggcaa gccgaacgtc
      1690       1700       1710       1720       1730       1740
cagcgtttta aaggtctggg ggaaatgaac ccgatgcaat tgcgcgaaac cacgcttgat
      1750       1760       1770       1780       1790       1800
ccgaacactc gccgtctggt gcagttgact atcgatgatg aagacgatca gcgtactgac
      1810       1820       1830       1840       1850       1860
gcgatgatgg atatgctgct ggcgaagaaa cgctcggaag atcgccgcaa ctggttgcaa
      1870       1880       1890
gagaaaggcg acatggcgga gattgaggtt taa  

Last modification date: Oct. 2, 2011