Escherichia coli Migula (bacterium) K-12 MG1655 [ECO]

FULL NAME: DNA topoisomerase 4 subunit A


DESCRIPTION:
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

STRUCTURE SIMILARITY:
Belongs to the topoisomerase GyrA/ParC subunit family.


PROTEIN TYPE(S):
DNA topoisomerase


RELATED PATHWAY(S):
DNA replication
prokaryotic nucleoid remodeling


Amino acids sequence

        10         20         30         40         50         60
MSDMAERLAL HEFTENAYLN YSMYVIMDRA LPFIGDGLKP VQRRIVYAMS ELGLNASAKF
        70         80         90        100        110        120
KKSARTVGDV LGKYHPHGDS ACYEAMVLMA QPFSYRYPLV DGQGNWGAPD DPKSFAAMRY
       130        140        150        160        170        180
TESRLSKYSE LLLSELGQGT ADWVPNFDGT LQEPKMLPAR LPNILLNGTT GIAVGMATDI
       190        200        210        220        230        240
PPHNLREVAQ AAIALIDQPK TTLDQLLDIV QGPDYPTEAE IITSRAEIRK IYENGRGSVR
       250        260        270        280        290        300
MRAVWKKEDG AVVISALPHQ VSGARVLEQI AAQMRNKKLP MVDDLRDESD HENPTRLVIV
       310        320        330        340        350        360
PRSNRVDMDQ VMNHLFATTD LEKSYRINLN MIGLDGRPAV KNLLEILSEW LVFRRDTVRR
       370        380        390        400        410        420
RLNYRLEKVL KRLHILEGLL VAFLNIDEVI EIIRNEDEPK PALMSRFGLT ETQAEAILEL
       430        440        450        460        470        480
KLRHLAKLEE MKIRGEQSEL EKERDQLQGI LASERKMNNL LKKELQADAQ AYGDDRRSPL
       490        500        510        520        530        540
QEREEAKAMS EHDMLPSEPV TIVLSQMGWV RSAKGHDIDA PGLNYKAGDS FKAAVKGKSN
       550        560        570        580        590        600
QPVVFVDSTG RSYAIDPITL PSARGQGEPL TGKLTLPPGA TVDHMLMESD DQKLLMASDA
       610        620        630        640        650        660
GYGFVCTFND LVARNRAGKA LITLPENAHV MPPVVIEDAS DMLLAITQAG RMLMFPVSDL
       670        680        690        700        710        720
PQLSKGKGNK IINIPSAEAA RGEDGLAQLY VLPPQSTLTI HVGKRKIKLR PEELQKVTGE
       730        740        750
RGRRGTLMRG LQRIDRVEID SPRRASSGDS EE  

Encoded by parC gene


OTHER NAME(S):
ECK3010
JW2987


DESCRIPTION:
ParC physically interacts with SeqA. [More information is available at EcoGene: EG10686]. The purified ParC protein is a dimer in solution . [More information is available at EcoCyc: EG10686].


Nucleic acid sequence

        10         20         30         40         50         60
atgagcgata tggcagagcg ccttgcgcta catgaattta cggaaaacgc ctacttaaac
        70         80         90        100        110        120
tactccatgt acgtgatcat ggaccgtgcg ttgccgttta ttggtgatgg tctgaaacct
       130        140        150        160        170        180
gttcagcgcc gcattgtgta tgcgatgtct gaactgggcc tgaatgccag cgccaaattt
       190        200        210        220        230        240
aaaaaatcgg cccgtaccgt cggtgacgta ctgggtaaat accatccgca cggcgatagc
       250        260        270        280        290        300
gcctgttatg aagcgatggt cctgatggcg caaccgttct cttaccgtta tccgctggtt
       310        320        330        340        350        360
gatggtcagg ggaactgggg cgcgccggac gatccgaaat cgttcgcggc aatgcgttac
       370        380        390        400        410        420
accgaatccc ggttgtcgaa atattccgag ctgctattga gcgagctggg gcaggggacg
       430        440        450        460        470        480
gctgactggg tgccaaactt cgacggcact ttgcaggagc cgaaaatgct acctgcccgt
       490        500        510        520        530        540
ctgccaaaca ttttgcttaa cggcaccacc ggtattgccg tcggcatggc gaccgatatt
       550        560        570        580        590        600
ccaccgcata acctgcgtga agtggctcag gcggcaatcg cattaatcga ccagccgaaa
       610        620        630        640        650        660
accacgctcg atcagctgct ggatatcgtg caggggccgg attatccgac tgaagcggaa
       670        680        690        700        710        720
attatcactt cgcgcgccga gatccgtaaa atctacgaga acggacgtgg ttcagtgcgt
       730        740        750        760        770        780
atgcgcgcgg tgtggaagaa agaagatggc gcggtggtta tcagcgcatt gccgcatcag
       790        800        810        820        830        840
gtttcaggtg cgcgcgtact ggagcaaatt gctgcgcaaa tgcgcaacaa aaagctgccg
       850        860        870        880        890        900
atggttgacg atctgcgcga tgaatctgac cacgagaacc cgacccgcct ggtgattgtg
       910        920        930        940        950        960
ccgcgttcca accgcgtgga tatggatcag gtgatgaacc acctcttcgc taccaccgat
       970        980        990       1000       1010       1020
ctggaaaaga gctatcgtat taaccttaat atgatcggtc tggatggtcg tccggcggtg
      1030       1040       1050       1060       1070       1080
aaaaacctgc tggaaatcct ctccgaatgg ctggtgttcc gccgcgatac cgtgcgccgc
      1090       1100       1110       1120       1130       1140
cgactgaact atcgtctgga gaaagtcctc aagcgcctgc atatcctcga aggtttgctg
      1150       1160       1170       1180       1190       1200
gtggcgtttc tcaatatcga cgaagtgatt gagatcattc gtaatgaaga tgaaccgaaa
      1210       1220       1230       1240       1250       1260
ccggcgctga tgtcgcggtt tggccttacg gaaacccagg cggaagcgat cctcgaactg
      1270       1280       1290       1300       1310       1320
aaactgcgtc atcttgccaa actggaagag atgaagattc gcggtgagca gagtgaactg
      1330       1340       1350       1360       1370       1380
gaaaaagagc gcgaccagtt gcagggcatt ttggcttccg agcgtaaaat gaataacctg
      1390       1400       1410       1420       1430       1440
ctgaagaaag aactgcaggc agacgcgcaa gcctacggtg acgatcgtcg ttcgccgttg
      1450       1460       1470       1480       1490       1500
caggaacgcg aagaagcgaa agcgatgagc gagcacgaca tgctgccgtc tgaacctgtc
      1510       1520       1530       1540       1550       1560
accattgtgc tgtcgcagat gggctgggta cgcagcgcta aaggccatga tatcgacgcg
      1570       1580       1590       1600       1610       1620
ccgggcctga attataaagc gggtgatagc ttcaaagcgg cggtgaaagg taagagcaac
      1630       1640       1650       1660       1670       1680
caaccggtag tgtttgttga ttccaccggt cgtagctatg ccattgaccc gattacgctg
      1690       1700       1710       1720       1730       1740
ccgtcggcgc gtggtcaggg cgagccgctc accggcaaat taacgttgcc gcctggggcg
      1750       1760       1770       1780       1790       1800
accgttgacc atatgctgat ggaaagcgac gatcagaaac tgctgatggc ttccgatgcg
      1810       1820       1830       1840       1850       1860
ggttacggtt tcgtctgcac ctttaacgat ctggtggcgc gtaaccgtgc aggtaaggct
      1870       1880       1890       1900       1910       1920
ttgatcacct taccggaaaa tgcccatgtt atgccgccgg tggtgattga agatgcttcc
      1930       1940       1950       1960       1970       1980
gatatgctgc tggcaatcac tcaggcaggc cgtatgttga tgttcccggt aagtgatctg
      1990       2000       2010       2020       2030       2040
ccgcagctgt cgaagggcaa aggcaacaag attatcaaca ttccatcggc agaagccgcg
      2050       2060       2070       2080       2090       2100
cgtggagaag atggtctggc gcaattgtac gttctgccgc cgcaaagcac gctgaccatt
      2110       2120       2130       2140       2150       2160
catgttggga aacgcaaaat taaactgcgc ccggaagagt tacagaaagt cactggcgaa
      2170       2180       2190       2200       2210       2220
cgtggacgcc gcggtacgtt gatgcgcggt ttgcagcgta tcgatcgtgt tgagatcgac
      2230       2240       2250
tctcctcgcc gtgccagcag cggtgatagc gaagagtaa  

Last modification date: Oct. 2, 2011