Drosophila melanogaster Meigen (fruit fly) [DME]

FULL NAME: DNA-directed RNA polymerases I, II, and III subunit RPABC2


DESCRIPTION:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB6 is part of the clamp element and togther with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).

STRUCTURE SIMILARITY:
Belongs to the archaeal rpoK/eukaryotic RPB6 RNA polymerase subunit family.


RELATED PATHWAY(S):
transcription


Amino acids sequence

        10         20         30         40         50         60
MDDADYDNDD VGGDDFDDVD EDVDEDINQE EEADNIEIIA PGGAGGGGVP KSKRITTKYM
        70         80         90        100        110        120
TKYERARVLG TRALQIAMCA PIMVELDGET DPLQIAMKEL KQKKIPIIIR RYLPDHSYED
       130
WSIDELIMVD N    

Encoded by RpII18 gene

FULL NAME: RNA polymerase II 18kD subunit


OTHER NAME(S):
BcDNA:RH21608
CG1163
Dm6
Dmel\CG1163
H5
pol II
Pol II
polII
PolII
RNA pol II
RNA Pol II
RNA polII
RNAP
RNAP II
RNApolII
RpABC14
RPB6_DROME
Rpll18


Nucleic acid sequence

        10         20         30         40         50         60
atggatgatg cggactacga caacgacgac gttggcggcg atgacttcga cgacgtcgac
        70         80         90        100        110        120
gaggacgtgg acgaggacat taaccaggag gaggaggcgg acaacatcga gatcatagct
       130        140        150        160        170        180
cccggtggtg cgggcggagg cggtgtgccc aagtccaagc gcattaccac aaagtacatg
       190        200        210        220        230        240
acgaaatacg agcgcgccag agttctgggc acacgagcgc ttcagatcgc catgtgcgca
       250        260        270        280        290        300
cccatcatgg tggagctgga cggggaaacg gaccccctgc agatcgccat gaaagagctg
       310        320        330        340        350        360
aaacaaaaga aaattcccat catcatccgc cgatacctgc cggatcactc ctacgaggac
       370        380        390
tggagcatcg acgagctcat catggtggac aactag  

Last modification date: Oct. 2, 2011