Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: DNA replication licensing factor mcm7


DESCRIPTION:
Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity). Required for the progression of S phase.

STRUCTURE SIMILARITY:
Contains 1 MCM domain.
Belongs to the MCM family.


CATALYTIC ACTIVITY:
ATP + H(2)O = ADP + phosphate.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MALPTIDLKI PEYEECQHKI TDFLSHFKQE QVQDGQQNQD ISMSDAGDEP FLKSKYMDIL
        70         80         90        100        110        120
QKISNRESNV INVDLNDLYE FDPSDTQLLH NIESNAKRFV ELFSQCADAL MPPPTVEINY
       130        140        150        160        170        180
RNEVLDVIMQ QRVQRNENID PEHKGFPPEL TRGYDLYFRP VTRNKKPFSV RDLRGENLGS
       190        200        210        220        230        240
LLTVRGIVTR TSDVKPSLTV NAYTCDRCGY EVFQEIRQKT FLPMSECPSD ECKKNDAKGQ
       250        260        270        280        290        300
LFMSTRASKF LPFQEVKIQE LTNQVPIGHI PRSLTVHLYG AITRSVNPGD IVDISGIFLP
       310        320        330        340        350        360
TPYTGFRAMR AGLLTDTYLE CHYVSQIIKN YTNIEKTPQS EAAIAELNQG GNVYEKLAKS
       370        380        390        400        410        420
IAPEIYGHED VKKALLLLLV GGVTKELGDG MRIRGDINIC LTGDPGVAKS QLLKYISKVA
       430        440        450        460        470        480
PRGVYTTGRG SSGVGLTAAV MRDPVTDEMV LEGGALVLAD NGICCIDEFD KMDESDRTAI
       490        500        510        520        530        540
HEVMEQQTIS ISKAGITTTL NARTSILAAA NPLYGRYNPK VAPIHNINLP AALLSRFDIL
       550        560        570        580        590        600
FLILDTPSRE TDEHLAQHVT YVHMHNEQPK MDFEPLDPNM IRHYISSARQ YRPVVPKDVC
       610        620        630        640        650        660
DYVTGAYVQL RQNQKRDEAN ERQFAHTTPR TLLAILRMGQ ALARLRFSNR VEIGDVDEAL
       670        680        690        700        710        720
RLMSVSKSSL YDDLDPSSHD TTITSKIYKI IRDMLNSIPD VEGNERSLTL RAIRERVLAK
       730        740        750        760
GFTEDHLINT IQEYTDLGVL LTTNNGQTIM FLDPDLHMEN  

Encoded by mcm7 gene


Nucleic acid sequence

        10         20         30         40         50         60
atggcacttc ccaccataga tttaaaaatc ccagagtatg aagaatgtca acataaaatt
        70         80         90        100        110        120
acggattttc tatcccactt caagcaggaa caggttcaag atggacaaca aaatcaggat
       130        140        150        160        170        180
atttcgatgt cggatgcagg tgatgagcct tttttaaaat caaagtatat ggatatacta
       190        200        210        220        230        240
caaaaaatct ccaatcgaga gtcaaatgtt attaatgttg atttgaatga tttgtacgag
       250        260        270        280        290        300
ttcgatccaa gtgatactca gcttttgcat aatattgaat ctaatgctaa acggtttgtt
       310        320        330        340        350        360
gaactttttt cgcagtgcgc agatgcgttg atgcctcctc ctactgtgga aattaattat
       370        380        390        400        410        420
cgcaacgaag tacttgatgt aattatgcag caacgtgttc aaaggaatga aaatatagac
       430        440        450        460        470        480
cctgagcata aaggatttcc tcctgaatta acccgaggtt atgacttata ctttcgacca
       490        500        510        520        530        540
gtaactcgca acaaaaaacc attcagcgtt cgtgatttaa gaggcgaaaa cttgggatct
       550        560        570        580        590        600
cttttgactg tccgtggtat agttactcgt acaagtgatg ttaagcctag cttaactgta
       610        620        630        640        650        660
aatgcttata catgtgatcg atgtgggtat gaagtgtttc aagaaatccg tcagaagaca
       670        680        690        700        710        720
ttccttccaa tgtctgaatg tccttcggat gaatgtaaaa agaatgatgc aaaaggtcag
       730        740        750        760        770        780
cttttcatga gcacaagagc cagtaaattt cttccttttc aggaagtaaa aatacaagaa
       790        800        810        820        830        840
ttaacgaacc aagtacctat tggccatatc cctagatcat taaccgtcca cttatatggt
       850        860        870        880        890        900
gctatcactc gctctgtaaa tcctggcgat atcgttgata tttctggtat atttttgccg
       910        920        930        940        950        960
actccgtata ctggttttcg agcaatgcgc gccgggctct taaccgatac ttacttagaa
       970        980        990       1000       1010       1020
tgccattatg tttcacaaat cattaaaaat tacacaaata ttgaaaaaac tcctcaatcg
      1030       1040       1050       1060       1070       1080
gaggctgcta tcgctgaatt aaatcaagga ggcaatgtgt acgaaaaact ggccaagtcc
      1090       1100       1110       1120       1130       1140
attgctcccg agatatatgg acatgaagat gttaaaaaag ctttacttct gttgcttgtc
      1150       1160       1170       1180       1190       1200
ggaggtgtta ctaaagagtt aggggatgga atgagaattc gtggtgacat aaatatttgt
      1210       1220       1230       1240       1250       1260
ttaactggtg atcctggtgt cgcaaaatct caattattaa agtatatttc gaaggttgcc
      1270       1280       1290       1300       1310       1320
ccgagaggag tatacaccac aggtcgtgga tcttcaggtg ttggtttaac tgctgctgta
      1330       1340       1350       1360       1370       1380
atgcgtgatc cagtgacgga tgaaatggtt ttagagggag gtgccttagt acttgctgac
      1390       1400       1410       1420       1430       1440
aacggtattt gctgcattga cgaatttgat aagatggatg aaagtgaccg tacagcaatt
      1450       1460       1470       1480       1490       1500
catgaagtaa tggaacagca aactatttca atttcaaagg caggaatcac tacgacttta
      1510       1520       1530       1540       1550       1560
aatgctcgaa caagtatttt ggccgctgcg aaccccttat atggacgata taatccgaaa
      1570       1580       1590       1600       1610       1620
gtggcaccaa tccacaatat aaatcttcca gctgcactgc tttcccggtt tgatatttta
      1630       1640       1650       1660       1670       1680
tttttaattt tagatactcc ttctcgtgaa acagacgagc atttggcaca acacgtaaca
      1690       1700       1710       1720       1730       1740
tatgttcaca tgcataacga acaacctaaa atggactttg aaccattaga tccaaacatg
      1750       1760       1770       1780       1790       1800
attaggcatt atatttcttc tgctagacaa tatcgcccag tcgtaccaaa ggatgtatgc
      1810       1820       1830       1840       1850       1860
gactatgtta ctggtgctta tgttcaactt cgacaaaacc aaaagcgtga tgaagccaat
      1870       1880       1890       1900       1910       1920
gagcgtcaat tcgctcacac tactccacgt acacttctcg ctattttgcg aatgggacaa
      1930       1940       1950       1960       1970       1980
gcattagctc gtttgcgttt cagtaataga gtggagattg gcgatgttga tgaagctttg
      1990       2000       2010       2020       2030       2040
agattaatgt ctgtttcaaa gtcatcacta tacgatgatt tggatcctag ttctcacgat
      2050       2060       2070       2080       2090       2100
actactatta cctcgaaaat atataaaatt attcgagaca tgcttaatag cataccagat
      2110       2120       2130       2140       2150       2160
gttgaaggca atgaacgctc acttacacta cgtgctattc gtgaacgcgt acttgctaag
      2170       2180       2190       2200       2210       2220
ggttttactg aagatcattt aataaataca atacaggaat atacagacct tggtgttctt
      2230       2240       2250       2260       2270       2280
ttaactacaa acaatggtca aacaataatg ttcctcgatc cggatttaca tatggagaat

taa     

Last modification date: Oct. 2, 2011