Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: DNA replication licensing factor mcm6


DESCRIPTION:
Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity).

STRUCTURE SIMILARITY:
Contains 1 MCM domain.
Belongs to the MCM family.


CATALYTIC ACTIVITY:
ATP + H(2)O = ADP + phosphate.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MSSLASQGNN ASTPAYRYGF QTSEVGDRPT VSMPSQPESS AMLEDDGMVK RKPFAAIGEA
        70         80         90        100        110        120
IPKVIDTTGE SVREAFEEFL LSFSDDRVAG GDALPSASQE KYYVQQIHGL AMYEIHTVYV
       130        140        150        160        170        180
DYKHLTSYND VLALAIVEQY YRFSPFLLRA LQKLIEKFEP EYYRSSLSRE NASLSPNFKA
       190        200        210        220        230        240
SDKTFALAFY NLPFRSTIRD LRTDRIGRLT TITGTVTRTS EVRPELAQGT FICEECHTVV
       250        260        270        280        290        300
SNVEQAFRYT EPTQCPNELC ANKRSWRLNI SQSSFQDWQK VRIQENSNEI PTGSMPRTLD
       310        320        330        340        350        360
VILRGDIVER AKAGDKCAFT GILIAVPDVS QLGIPGVKPE AYRDSRNFGG RDADGVTGLK
       370        380        390        400        410        420
SLGVRDLTYK LSFLACMVQP DDANDKSGAD VRGDGSQGIE EQDEFLQSLS QEEIDDLRAM
       430        440        450        460        470        480
VHSDHIYSRL TNSLAPSVYG HEIIKKGILL QLMGGVHKLT PEGINLRGDL NICIVGDPST
       490        500        510        520        530        540
SKSQFLKYVC NFLPRAIYTS GKASSAAGLT AAVVKDEETG DFTIEAGALM LADNGICAID
       550        560        570        580        590        600
EFDKMDLSDQ VAIHEAMEQQ TISIAKAGIQ ATLNARTSIL AAANPIGGRY NRKTTLRNNI
       610        620        630        640        650        660
NMSAPIMSRF DLFFVVLDEC NESVDRHLAK HIVDIHRLRD DAMQPEFSTE QLQRYIRYAR
       670        680        690        700        710        720
TFKPKLNTES CAEIVKKYKQ LRMDDAQGAG KNSYRITVRQ LESMIRLSEA IARANCVDDI
       730        740        750        760        770        780
TPAFVNEAYS LLRQSIIHVE RDDIEVEEDD AEAQELENDN TNTTNGNDNV SSEEALQKPK
       790        800        810        820        830        840
VKITYDKYVS IMNGILQVLR QRSTEGVDGV PAGDLVQSYL ELREDQFHTE EDIIYEVGLV
       850        860        870        880        890
RKVLTRLVHE SIIMEIQNLT DSAVRLPFEE RVFSIHPNCD IDALLSNGDV PN

Encoded by mcm6 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgtcttctc ttgcatctca gggtaataat gcttcaactc ctgcatatcg ttatgggttt
        70         80         90        100        110        120
caaacttcag aagttgggga caggccaact gtaagtatgc cttcacaacc tgagtcgagt
       130        140        150        160        170        180
gctatgctcg aggatgatgg aatggtgaaa aggaaacctt ttgctgctat aggagaagcc
       190        200        210        220        230        240
ataccaaagg taattgatac aaccggagaa tcagtacgtg aagcctttga agagttttta
       250        260        270        280        290        300
ttgtcatttt ctgatgaccg cgttgctgga ggtgatgctc tcccttctgc atcacaagag
       310        320        330        340        350        360
aaatattatg ttcaacagat tcatggattg gcaatgtatg agattcatac cgtttacgtt
       370        380        390        400        410        420
gattataagc atttaacctc gtacaatgat gtgttagctc ttgcgatagt tgagcaatat
       430        440        450        460        470        480
tatcgatttt ctcctttctt acttcgagct ttacaaaagt tgattgaaaa gtttgaacca
       490        500        510        520        530        540
gaatattata gaagttctct ttctcgtgaa aatgcttcac tttcaccgaa ctttaaagcc
       550        560        570        580        590        600
agtgacaaaa catttgctct tgcattttac aatttaccct ttcgatccac aattcgggac
       610        620        630        640        650        660
ttacgaacag atcgtatcgg tagactcacg actattacag gtacagttac tcgtacttct
       670        680        690        700        710        720
gaagtacgcc ctgaattagc acaaggtact tttatctgtg aggaatgcca cactgtagtt
       730        740        750        760        770        780
tcaaatgttg agcaagcatt tcgctatact gaaccaactc aatgccctaa tgaactttgt
       790        800        810        820        830        840
gctaataaaa gaagttggcg gctcaatatt tcacagtctt cttttcagga ctggcaaaag
       850        860        870        880        890        900
gtgcgcattc aagaaaatag caacgagatt cctacgggtt ctatgccacg aactttggac
       910        920        930        940        950        960
gtaattttgc gcggagatat tgttgaaagg gctaaggctg gtgacaaatg cgcatttacg
       970        980        990       1000       1010       1020
ggaattctta ttgccgttcc agatgtctca cagctaggaa ttcctggtgt aaagccagaa
      1030       1040       1050       1060       1070       1080
gcttatcgag attctcgcaa ttttggtggt agagatgcag atggtgtgac aggactgaag
      1090       1100       1110       1120       1130       1140
tctttaggtg tacgtgatct tacatataaa ctatcttttt tagcttgcat ggttcaacca
      1150       1160       1170       1180       1190       1200
gatgatgcaa atgataaaag cggtgcggat gtcagagggg atggttctca agggatcgaa
      1210       1220       1230       1240       1250       1260
gagcaagatg aatttttgca atcgctttct caagaagaaa ttgatgattt acgtgcgatg
      1270       1280       1290       1300       1310       1320
gtgcattcag atcatattta ttctcgtttg acaaactcac tggctccctc tgtttatggt
      1330       1340       1350       1360       1370       1380
catgaaataa ttaagaaggg gattctttta cagttaatgg gtggtgttca caagttaact
      1390       1400       1410       1420       1430       1440
cctgaaggta taaatcttcg tggcgacctg aacatttgta ttgtcggcga ccccagtact
      1450       1460       1470       1480       1490       1500
tcgaaatcac aatttcttaa atacgtttgc aattttcttc ctcgtgcaat ctacacttct
      1510       1520       1530       1540       1550       1560
ggaaaggcat catctgcggc cggtctcaca gctgcagttg ttaaggacga agaaactggg
      1570       1580       1590       1600       1610       1620
gattttacta tagaagcagg cgctttaatg ttggctgaca atggaatatg tgctatagat
      1630       1640       1650       1660       1670       1680
gaattcgata aaatggatct gtcagaccaa gttgctattc atgaagcaat ggaacaacaa
      1690       1700       1710       1720       1730       1740
acgatatcta tagcaaaagc tggaattcaa gctacattaa acgcacggac atctatcctt
      1750       1760       1770       1780       1790       1800
gctgctgcaa atccaatagg tggccgctat aaccgaaaaa caactttgcg gaataacatc
      1810       1820       1830       1840       1850       1860
aatatgtctg ctcctatcat gtcacggttt gatttattct tcgttgtact agatgagtgc
      1870       1880       1890       1900       1910       1920
aatgaatcag ttgatagaca tttagctaag catattgttg acattcatcg tttacgggat
      1930       1940       1950       1960       1970       1980
gatgccatgc aacctgaatt tagtactgag caacttcaac gatatatcag atatgcaagg
      1990       2000       2010       2020       2030       2040
actttcaaac caaagttaaa tacagaatct tgtgccgaaa ttgttaaaaa gtacaagcaa
      2050       2060       2070       2080       2090       2100
ttgcggatgg atgacgcgca aggtgctggt aaaaattcat atcgtattac cgtgcgacaa
      2110       2120       2130       2140       2150       2160
ctggagtcaa tgattcgtct atcagaagcc attgcaagag caaactgtgt agatgatatt
      2170       2180       2190       2200       2210       2220
actcctgcat ttgtcaacga agcatactct ttattacgtc aatcaattat ccatgtggaa
      2230       2240       2250       2260       2270       2280
agagatgata ttgaggttga agaagatgat gcagaggccc aagaacttga gaatgataat
      2290       2300       2310       2320       2330       2340
actaatacaa caaatggcaa tgataatgtt tcttcggaag aagctttgca gaaaccaaaa
      2350       2360       2370       2380       2390       2400
gtaaaaatta cttacgacaa atatgtttcg attatgaacg gaatattaca ggttttacgc
      2410       2420       2430       2440       2450       2460
cagcgctcta ctgaaggtgt agatggagta ccagcgggag acctagttca gtcatatctc
      2470       2480       2490       2500       2510       2520
gagcttaggg aagaccaatt ccataccgag gaagacatca tctatgaggt tggtcttgtg
      2530       2540       2550       2560       2570       2580
cgtaaggtat taaccaggct tgttcacgaa tcgatcatca tggaaattca aaatttaact
      2590       2600       2610       2620       2630       2640
gacagcgccg tgaggcttcc ttttgaagaa cgcgtatttt caatacaccc taactgtgac
      2650       2660       2670
attgatgctc tactgagcaa tggcgatgtt ccgaactaa  

Last modification date: Oct. 2, 2011