Homo sapiens L. (human) [HSA]

FULL NAME: DNA polymerase delta subunit 3


DESCRIPTION:
Required for optimal DNA polymerase delta activity.

RELATED PATHWAY(S):
DNA replication
base excision repair (BER)
nucleotide excision repair (NER)
mismatch repair (MMR)
homologous recombination (HR)


Amino acids sequence

        10         20         30         40         50         60
MADQLYLENI DEFVTDQNKI VTYKWLSYTL GVHVNQAKQM LYDYVERKRK ENSGAQLHVT
        70         80         90        100        110        120
YLVSGSLIQN GHSCHKVAVV REDKLEAVKS KLAVTASIHV YSIQKAMLKD SGPLFNTDYD
       130        140        150        160        170        180
ILKSNLQNCS KFSAIQCAAA VPRAPAESSS SSKKFEQSHL HMSSETQANN ELTTNGHGPP
       190        200        210        220        230        240
ASKQVSQQPK GIMGMFASKA AAKTQETNKE TKTEAKEVTN ASAAGNKAPG KGNMMSNFFG
       250        260        270        280        290        300
KAAMNKFKVN LDSEQAVKEE KIVEQPTVSV TEPKLATPAG LKKSSKKAEP VKVLQKEKKR
       310        320        330        340        350        360
GKRVALSDDE TKETENMRKK RRRIKLPESD SSEDEVFPDS PGAYEAESPS PPPPPSPPLE
       370        380        390        400        410        420
PVPKTEPEPP SVKSSSGENK RKRKRVLKSK TYLDGEGCIV TEKVYESESC TDSEEELNMK
       430        440        450        460
TSSVHRPPAM TVKKEPREER KGPKKGTAAL GKANRQVSIT GFFQRK 

Encoded by POLD3 gene

FULL NAME: polymerase (DNA-directed), delta 3, accessory subunit


OTHER NAME(S):
KIAA0039
MGC119642
MGC119643
P66
P68


DESCRIPTION:
The DNA polymerase delta complex is involved in DNA replication and repair, and it consists of the proliferating cell nuclear antigen (PCNA; MIM 176740), the multisubunit replication factor C (see MIM 102579), and the 4 subunit polymerase complex: POLD1 (MIM 174761), POLD2 (MIM 600815), POLD3, and POLD4 (MIM 611525) (Liu and Warbrick, 2006 [PubMed 16934752]).[supplied by OMIM, Mar 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atggcggacc agctttatct ggaaaatata gacgagttcg tcacggacca aaacaagatc
        70         80         90        100        110        120
gtgacataca aatggctgag ctatacacta ggggttcatg ttaaccaggc caaacagatg
       130        140        150        160        170        180
ctgtatgatt atgttgaaag gaaacgaaaa gaaaattcag gagcccaact gcatgttacc
       190        200        210        220        230        240
tacttggtgt ctggcagtct cattcagaat ggacattcct gccacaaggt tgcagtagtg
       250        260        270        280        290        300
agagaagata aattggaagc agtgaagtcc aagctagctg tgactgccag catccatgtg
       310        320        330        340        350        360
tacagcatcc agaaagccat gctaaaggac agtgggcctc tgttcaatac tgactatgac
       370        380        390        400        410        420
atccttaaaa gcaacttgca gaactgcagc aaatttagtg ctatacaatg tgcagctgcc
       430        440        450        460        470        480
gtccctagag ctcctgctga atcctcttcg tcttccaaaa agtttgagca gtcacatctt
       490        500        510        520        530        540
cacatgtcaa gtgagacaca agccaacaat gagctgacca ccaatggtca tggcccacct
       550        560        570        580        590        600
gcatccaagc aggtttccca gcagcccaaa ggaattatgg gaatgtttgc ctccaaagct
       610        620        630        640        650        660
gctgctaaaa cccaagaaac caacaaggaa acgaaaacag aggctaaaga agtaacaaat
       670        680        690        700        710        720
gcatctgcag caggcaacaa ggcaccaggg aaagggaata tgatgagcaa cttttttgga
       730        740        750        760        770        780
aaagctgcta tgaataaatt taaagtcaat ttggactcag aacaagcagt gaaagaagaa
       790        800        810        820        830        840
aaaatagtgg agcagcctac agtgtctgtc acggaaccaa agctggcaac tcctgcaggc
       850        860        870        880        890        900
ctgaaaaaat ccagcaaaaa agcagagcct gttaaggtgc tgcagaagga aaaaaaaagg
       910        920        930        940        950        960
gggaagcgag tagcattatc tgatgatgag acaaaggaaa ctgaaaacat gaggaaaaag
       970        980        990       1000       1010       1020
aggagaagaa tcaaacttcc tgaatctgat agcagtgaag atgaagtctt tccagactct
      1030       1040       1050       1060       1070       1080
cctggggctt atgaagctga gtcaccatcc ccacctcctc ctccgtctcc acctcttgaa
      1090       1100       1110       1120       1130       1140
ccagtgccaa agactgagcc tgaacctcct tctgtcaaga gctcaagtgg agaaaacaaa
      1150       1160       1170       1180       1190       1200
agaaaacgaa aacgcgtact aaaatctaaa acttacctgg atggggaagg ctgcatagtg
      1210       1220       1230       1240       1250       1260
actgaaaaag tctacgagag tgaatcctgc acagatagtg aagaggagct taacatgaag
      1270       1280       1290       1300       1310       1320
acatcctcag tacacagacc ccctgccatg actgtgaaaa aagaacccag agaggaacga
      1330       1340       1350       1360       1370       1380
aagggcccca agaaagggac tgctgctctg ggcaaagcca acagacaggt gtccattact
      1390       1400
ggcttcttcc agaggaaata a   

Last modification date: Oct. 2, 2011