homologous recombination (HR)

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DESCRIPTION:

Homologous recombination repair (HRR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.

ABBREVIATIONS:
HR
HRR


OTHER NAME(S):
homologous recombination repair


RELATED DISEASES:


DAMAGES RECOGNIZED AND REMOVED:


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ORTHOLOGY CLASS Homo sapiens L. (human) [HSA] Mus musculus L. (mouse) [MMU] Caenorhabditis elegans Maupas (nematode) [CEL] Drosophila melanogaster Meigen (fruit fly) [DME] Saccharomyces cerevisiae Meyen ex E.C. Hansen (budding yeast) [SCE] Schizo-saccharomyces pombe Lindner (fission yeast) [SPO] Escherichia coli Migula (bacterium) K-12 MG1655 [ECO] Arabidopsis thaliana (L.) Heynh. (mouse-ear cress) [ATH]
ko:K10959 (DNA repair protein RAD59) RAD59
ko:K10958 (DNA repair protein RAD57) RAD57 rhp57
ko:K10957 (DNA repair protein RAD55) RAD55
ko:K10901 (bloom syndrome protein [EC:3.6.4.12]) RECQL3 (BLM) Blm him-6 mus309 SGS1 rqh1 gi:240254298
RECQI1
RECQ4A
ko:K10882 (crossover junction endonuclease EME1 [EC:3.1.22.-]) EME1 Eme1 mms4 eme1 gi:240254508
gi:79559555
ko:K10881 (26 proteasome complex subunit DSS1) SHFM1 Shfm1 dss-1 gi:21358401 SEM1 dss1 gi:15241644
gi:18408121
ko:K10880 (DNA-repair protein XRCC3) XRCC3 Xrcc3 spn-B XRCC3
ko:K10879 (DNA-repair protein XRCC2) XRCC2 Xrcc2 XRCC2
ko:K10877 (DNA repair and recombination protein RAD54B [EC:3.6.4.-]) RAD54B
RAD54B
Rad54b gi:71995707 RDH54
RDH54
rdh54
ko:K10875 (DNA repair and recombination protein RAD54 and RAD54-like protein [EC:3.6.4.-]) RAD54L Rad54l rad-54 okr RAD54 rhp54 gi:145338703
ko:K10873 (DNA repair and recombination protein RAD52) RAD52 Rad52 RAD52 rti1
rad22
ko:K10871 (RAD51-like protein 3) RAD51L3 Rad51l3
ko:K10870 (RAD51-like protein 2) RAD51C Rad51c spn-D gi:18406752
ko:K10869 (RAD51-like protein 1) RAD51L1 Rad51l1 RAD51B
ko:K10868 (DNA repair protein XRS2) XRS2
ko:K10867 (nijmegen breakage syndrome protein 1) NBN (NBS1) Nbn nbs NBS1
ko:K10866 (DNA repair protein RAD50 [EC:3.6.-.-]) RAD50 Rad50 rad-50 rad50 RAD50 rad50 RAD50
ko:K10865 (double-strand break repair protein MRE11) MRE11A Mre11a mre-11 mre11 MRE11 rad32 MRE11
ko:K10741 (replication factor A4) RPA4
ko:K10740 (replication factor A3) RPA3 Rpa3 Dmel_CG15220 ssb3 At4g18590
F3C22_30
ko:K10739 (replication factor A2) RPA2 Rpa2 rpa-2
rpa-4
RPA2 RFA2 ssb2 RPA2
RPA32B
ko:K08991 (crossover junction endonuclease MUS81 [EC:3.1.22.-]) MUS81 Mus81 mus-81 mus81 MUS81 mus81 gi:240256383
MUS81
ko:K08775 (breast cancer 2 susceptibility protein) BRCA2 (FANCD1) Brca2 BRCA2(IV)
BRCA2B
ko:K07466 (replication factor A1) RPA1 Rpa1 rpa-1 RpA-70 RFA1 ssb1 RPA1A
ko:K07462 (single-stranded-DNA-specific exonuclease [EC:3.1.-.-]) RecJ
ko:K06187 (recombination protein RecR) RecR
ko:K04482 (DNA repair protein RAD51) RAD51 Rad51 rad-51 spn-A RAD51 rhp51 gi:18420327
ko:K04067 (primosomal replication protein N'') priC
ko:K04066 (primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:3.6.4.-]) PriA
ko:K03655 (ATP-dependent DNA helicase RecG [EC:3.6.4.12]) RecG gi:186498546
ko:K03629 (DNA replication and repair protein RecF) RecF
ko:K03584 (DNA repair protein RecO (recombination protein O)) RecO
ko:K03583 (exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]) RecC
ko:K03582 (exodeoxyribonuclease V beta subunit [EC:3.1.11.5]) RecB
ko:K03581 (exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]) RecD
ko:K03553 (recombination protein RecA) RecA recA3-like
ko:K03551 (holliday junction DNA helicase RuvB [EC:3.6.4.12]) RuvB
ko:K03550 (holliday junction DNA helicase RuvA [EC:3.6.4.12]) RuvA
ko:K03505 (DNA polymerase delta subunit 4) POLD4 Pold4 cdm1 POLD4
ko:K03504 (DNA polymerase delta subunit 3) POLD3 Pold3 PolD3 CG3975
Dmel_CG3975
POL32 cdc27 POLD3
ko:K03165 (DNA topoisomerase III [EC:5.99.1.2]) TOP3B
TOP3A
Top3b
Top3a
top-3
Top-3
Top3alpha
Top3beta
TOP3 top3 TOP3A
ko:K03111 (single-strand DNA-binding protein) SSBP1 Ssbp1 mtSSB Ssb At3g18580
ko:K02686 (primosomal replication protein N) priB
ko:K02345 (DNA polymerase III subunit theta [EC:2.7.7.7]) HolE
ko:K02344 (DNA polymerase III subunit psi [EC:2.7.7.7]) HolD
ko:K02343 (DNA polymerase III subunit gamma/tau [EC:2.7.7.7]) DnaX
ko:K02342 (DNA polymerase III subunit epsilon [EC:2.7.7.7]) DnaQ
ko:K02341 (DNA polymerase III subunit delta' [EC:2.7.7.7]) HolB
ko:K02340 (DNA polymerase III subunit delta [EC:2.7.7.7]) HolA
ko:K02339 (DNA polymerase III subunit chi [EC:2.7.7.7]) HolC
ko:K02338 (DNA polymerase III subunit beta [EC:2.7.7.7]) DnaN
ko:K02337 (DNA polymerase III subunit alpha [EC:2.7.7.7]) DnaE (PolC)
ko:K02335 (DNA polymerase I [EC:2.7.7.7]) DNA Pol I POLGAMMA2
POLGAMMA1
ko:K02328 (DNA polymerase delta subunit 2) POLD2 Pold2 DNA Pol delta sub 2 DNA pol delta small sub POL31 cdc1 POLD2
ko:K02327 (DNA polymerase delta subunit 1 [EC:2.7.7.7]) POLδ (POLD) mPolδ (mPolD) DNA Pol delta DNApol-delta POL3
POL3
cdc6 POLD1
ko:K02317 (DNA replication protein DnaT) DnaT
ko:K01159 (crossover junction endodeoxyribonuclease RuvC [EC:3.1.22.4]) RuvC

References:

  • Shu proteins promote the formation of homologous recombination intermediates that are processed by Sgs1-Rmi1-Top3.

    , , : [PUBMED]
  • Holliday junction-containing DNA structures persist in cells lacking Sgs1 or Top3 following exposure to DNA damage.

    , , : [PUBMED]
  • Processing of homologous recombination repair Intermediates by the Sgs1-Top3-Rmi1 and Mus81-Mms4 complexes.

    , , : [PUBMED]
  • Homologous recombination in human embryonic stem cells: a tool for advancing cell therapy and understanding and treating human disease.

    , , : [PUBMED]
  • Break-induced replication and telomerase-independent telomere maintenance require Pol32.

    , , : [PUBMED]
  • Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly.

    , , : [PUBMED]

Last modification date: Oct. 6, 2011