TARGET: DNA (cytosine-5)-methyltransferase inhibitor

DESCRIPTION:
DNA methyltransferases are a family of enzymes that catalyze the transfer of methyl group to DNA. There are five related DNA cytosine- 5-methyltransferases (DNMTs) that transfer a methyl group from S-adenosylmethionine (AdoMet, SAM) to the C-5 position of cytosine. Inhibitors have been shown to have anti-proliferative activity. They can reactivate the expression of genes that have been repressed by DNA methylation. There are two classes of inhibitors: - Non-nucleoside analog inhibitors. - Nucleoside analog inhibitors.

Filter

Click on a column header name to sort

DRUG STRUCTURE OTHER TARGET TYPE(S) DNAtraffic related PROTEIN(S)
PROCAINAMINE anti-cancer treatment
DNA (cytosine-5)-methyltransferase inhibitor
nucleic acids methylation inhibitor
Psammaplin A anti-cancer treatment
anti-bacterial treatment
DNA (cytosine-5)-methyltransferase inhibitor
nucleic acids methylation inhibitor
Decitabine DNA
RNA
anti-cancer treatment
other treatment
base analog
DNA (cytosine-5)-methyltransferase inhibitor
nucleic acids methylation inhibitor
Azacitidine DNA
RNA
anti-cancer treatment
protein synthesis inhibitor
base analog
DNA synthesis inhibitor
DNA (cytosine-5)-methyltransferase inhibitor
nucleic acids methylation inhibitor
DNMT3B
DNMT1
Dnmt1
DNMT3A
Dnmt3a
Dnmt3b
RG108 anti-cancer treatment
DNA (cytosine-5)-methyltransferase inhibitor
nucleic acids methylation inhibitor