TARGET: DNA topoisomerase inhibitor

DESCRIPTION:
Topoisomerase inhibitor: compounds that inhibit the enzymatic activity of topoisomerases. Topoisomerases I and II are involved in the interconversion of DNA forms differing in their linking number "L". Topoisomerase I acts by introducing transient nicks in the DNA, while topoisomerase II acts via intermediates containing double-stranded DNA cuts and requires ATP for its action. Type I topoisomerase cuts one strand of a DNA double helix, relaxation occurs, and then the cut strand is reannealed. Cutting one strand allows the part of the molecule on one side of the cut to rotate around the uncut strand, thereby reducing stress from too much or too little twist in the helix. Such stress is introduced when the DNA strand is "supercoiled" or uncoiled to or from higher orders of coiling. Type I topoisomerases are subdivided into two subclasses: type IA topoisomerases, which share many structural and mechanistic features with the type II topoisomerases, and type IB topoisomerases, which utilize a controlled rotary mechanism. Examples of type IA topoisomerases include topo I and topo III. In the past, type IB topoisomerases were referred to as eukaryotic topo I, but IB topoisomerases are present in all three domains of life. It is interesting to note that type IA topoisomerases form a covalent intermediate with the 5' end of DNA, while the IB topoisomerases form a covalent intermediate with the 3' end of DNA. Recently, a type IC topoisomerase has been identified, called topo V. While it is structurally unique from type IA and IB topoisomerases, it shares a similar mechanism with type IB topoisomerase.

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DRUG STRUCTURE OTHER TARGET TYPE(S) DNAtraffic related PROTEIN(S)
Ofloxacin DNA topoisomerase inhibitor
DNA synthesis inhibitor
GyrA
ParC
Norfloxacin anti-bacterial treatment
DNA topoisomerase inhibitor
DNA repair inhibitor
DNA synthesis inhibitor
transcription inhibitor
GyrA
ParC
Etoposide anti-cancer treatment
DNA-protein complex
DNA topoisomerase inhibitor
DNA repair inhibitor
DNA synthesis inhibitor
TOP2A
Idarubicin DNA
anti-cancer treatment
DNA-protein complex
DNA topoisomerase inhibitor
DNA repair inhibitor
DNA synthesis inhibitor
TOP2A
Ciprofloxacin anti-bacterial treatment
DNA topoisomerase inhibitor
DNA repair inhibitor
DNA synthesis inhibitor
RNA synthesis inhibitor
GyrA
ParC
Levofloxacin anti-bacterial treatment
DNA topoisomerase inhibitor
DNA repair inhibitor
DNA synthesis inhibitor
RNA synthesis inhibitor
GyrA
ParC
Rosoxacin anti-bacterial treatment
DNA topoisomerase inhibitor
DNA repair inhibitor
DNA synthesis inhibitor
GyrA
ParC
Pefloxacin deoxynucleic acid (DNA) synthesis inhibitor
anti-bacterial treatment
DNA topoisomerase inhibitor
DNA synthesis inhibitor
GyrA
ParC
Gatifloxacin deoxynucleic acid (DNA) synthesis inhibitor
anti-bacterial treatment
DNA topoisomerase inhibitor
DNA repair inhibitor
DNA synthesis inhibitor
transcription inhibitor
ParC
GyrA
Doxorubicin anti-cancer treatment
DNA-protein complex
deoxynucleic acid (DNA) synthesis inhibitor
DNA topoisomerase inhibitor
DNA repair inhibitor
DNA synthesis inhibitor
TOP2A
Lucanthone DNA
anti-cancer treatment
deoxynucleic acid (DNA) synthesis inhibitor
DNA topoisomerase inhibitor
DNA repair inhibitor
DNA synthesis inhibitor
APEX1
TOP2A
TOP1
Enoxacin anti-bacterial treatment
DNA topoisomerase inhibitor
DNA synthesis inhibitor
GyrA
IRINOTECAN anti-cancer treatment
DNA-protein complex
DNA topoisomerase inhibitor
DNA repair inhibitor
DNA synthesis inhibitor
TOP1
Genistein anti-cancer treatment
DNA topoisomerase inhibitor
DNA synthesis inhibitor
TOP2A
Fleroxacin anti-bacterial treatment
DNA topoisomerase inhibitor
DNA repair inhibitor
DNA synthesis inhibitor
transcription inhibitor
GyrA
Podofilox other treatment
DNA topoisomerase inhibitor
DNA repair inhibitor
DNA synthesis inhibitor
TOP2A
Sodium stibogluconate anti-cancer treatment
other treatment
DNA topoisomerase inhibitor
DNA synthesis inhibitor
transcription inhibitor
TOP1
Trovafloxacin anti-bacterial treatment
DNA topoisomerase inhibitor
DNA repair inhibitor
DNA synthesis inhibitor
GyrA
ParC
Amsacrine DNA
anti-cancer treatment
DNA topoisomerase inhibitor
DNA repair inhibitor
DNA synthesis inhibitor
TOP2A
Camptothecin anti-cancer treatment
DNA-protein complex
DNA topoisomerase inhibitor
DNA repair inhibitor
DNA synthesis inhibitor
TOP1
Dextrofloxacine anti-bacterial treatment
DNA topoisomerase inhibitor
DNA repair inhibitor
DNA synthesis inhibitor
GyrA
Clorobiocin anti-bacterial treatment
DNA topoisomerase inhibitor
DNA repair inhibitor
DNA synthesis inhibitor
RNA synthesis inhibitor
GyrB
GyrB
TOPOTECAN DNA
anti-cancer treatment
DNA-protein complex
deoxynucleic acid (DNA) synthesis inhibitor
DNA topoisomerase inhibitor
DNA repair inhibitor
DNA synthesis inhibitor
TOP1