TARGET: Reverse transcriptase inhibitor (RTI)

DESCRIPTION:
Reverse-transcriptase inhibitors (RTIs) are a class of antiretroviral drug used to treat HIV infection, tumors, and cancer. RTIs inhibit activity of reverse transcriptase, a viral DNA polymerase enzyme that retroviruses need to reproduce.

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DRUG STRUCTURE OTHER TARGET TYPE(S) DNAtraffic related PROTEIN(S)
Zidovudine DNA
anti-viral treatment
reverse transcriptase inhibitor (RTI)
base analog
DNA synthesis inhibitor
Zalcitabine DNA
deoxynucleic acid (DNA) synthesis inhibitor
anti-viral treatment
reverse transcriptase inhibitor (RTI)
base analog
Efavirenz protein type
anti-viral treatment
reverse transcriptase inhibitor (RTI)
Nevirapine deoxynucleic acid (DNA) synthesis inhibitor
anti-viral treatment
ribonucleic acid (RNA) synthesis inhibitor
reverse transcriptase inhibitor (RTI)
base analog
DNA-dependent RNA polymerase inhibitor
DNA-dependent DNA polymerase inhibitor
TERT (telomerase catalytic subunit)
Abacavir DNA
anti-viral treatment
reverse transcriptase inhibitor (RTI)
base analog
Telbivudine DNA
deoxynucleic acid (DNA) synthesis inhibitor
anti-viral treatment
reverse transcriptase inhibitor (RTI)
base analog
DNA synthesis inhibitor
Didanosine protein type
DNA
anti-viral treatment
reverse transcriptase inhibitor (RTI)
base analog
DNA synthesis inhibitor
Stavudine DNA
anti-viral treatment
reverse transcriptase inhibitor (RTI)
base analog
DNA synthesis inhibitor
Tenofovir deoxynucleic acid (DNA) synthesis inhibitor
anti-viral treatment
reverse transcriptase inhibitor (RTI)
base analog
POLα (POLA)
POLβ (POLB)
POLγ (POLG)
Adefovir Dipivoxil DNA
anti-viral treatment
reverse transcriptase inhibitor (RTI)
base analog
DNA-dependent DNA polymerase inhibitor
DNA synthesis inhibitor
POLγ (POLG)
POLα (POLA)