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Methoxsalen


ACCESSION NB: DB00553 (APRD00157)


TYPE: small molecule


GROUP: approved


DESCRIPTION:
A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation. [PubChem]

VOLUME OF DISTRIBUTION: Not Available

CATEGORIES:
Antineoplastic Agents Cross-Linking Reagents Photosensitizing Agents Pigmenting Agents

ABSORPTION: Not Available

INDICATION:
For the treatment of psoriasis and vitiligo

PHARMACODYNAMICS:
Methoxsalen selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Methoxsalen-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.

MECHANISM OF ACTION:
After activation it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function.

PROTEIN BINDING:
Not Available

TOXICITY:
Not Available

AFECTED ORGANISMS:
Humans and other mammals