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Pipobroman


ACCESSION NB: DB00236 (APRD00693)


TYPE: small molecule


GROUP: approved


DESCRIPTION:
An antineoplastic agent that acts by alkylation. [PubChem]

VOLUME OF DISTRIBUTION: Not Available

CATEGORIES:
Antineoplastic Agents Antineoplastic Agents, Alkylating

ABSORPTION: Well absorbed from the GI tract.

INDICATION:
For the treatment of polycythaemia vera and refractory chronic myeloid leukaemia.

PHARMACODYNAMICS:
Pipobroman is an antineoplastic agent. Specifically it is a piperazine derivative with a chemical structure close to that of many DNA alkylating agents. Pipobroman has well documented clinical activity against polycythemia vera and essential thrombocythemia.

MECHANISM OF ACTION:
The mechanism of action is uncertain but pipobroman is thought to alkylate DNA leading to disruption of DNA synthesis and eventual cell death.

PROTEIN BINDING:
Not Available

TOXICITY:
Symptoms of overdose include hematologic toxicity, especially with chronic overdosage.

AFECTED ORGANISMS:
Humans and other mammals