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Proflavine


ACCESSION NB: DB01123 (APRD00535)


TYPE: small molecule


GROUP: approved


DESCRIPTION:
3,6-Diaminoacridine. Topical antiseptic used mainly in wound dressings. [PubChem]

VOLUME OF DISTRIBUTION: Not Available

CATEGORIES:
Anti-Infective Agents, Local Anti-Infectives, local

ABSORPTION: Not Available

INDICATION:
Topical antiseptic used mainly in wound dressings.

PHARMACODYNAMICS:
Proflavine is an acriflavine derivative which is a disinfectant bacteriostatic against many gram-positive bacteria. Proflavine is toxic and carcinogenic in mammals and so it is used only as a surface disinfectant or for treating superficial wounds.

MECHANISM OF ACTION:
Proflavine acts by interchelating DNA (intercalation), thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands. This prevents bacterial reproduction.

PROTEIN BINDING:
Not Available

TOXICITY:
Not Available

AFECTED ORGANISMS:
Enteric bacteria and other eubacteria