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Genistein


ACCESSION NB: DB01645 (EXPT01582)


TYPE: small molecule


GROUP: experimental


DESCRIPTION:
An isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA topoisomerases, type II) activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 phase arrest in human and murine cell lines.

VOLUME OF DISTRIBUTION: Not Available

CATEGORIES:
Antineoplastic Agents Enzyme Inhibitors Growth Inhibitors Anticarcinogenic Agents Protein Kinase Inhibitors Phytoestrogens

ABSORPTION: Not Available

INDICATION:
Not Available

PHARMACODYNAMICS:
Not Available

MECHANISM OF ACTION:
Not Available

PROTEIN BINDING:
Not Available

METABOLISM:
Enzyme Metabolite Reaction Km Vmax Cytochrome P450 1A2 3'-hydroxygenistein 3'-hydroxylation 12.7 0.11

TOXICITY:
Not Available

AFECTED ORGANISMS:
Humans and other mammals