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Fleroxacin


ACCESSION NB: DB04576


TYPE: small molecule


GROUP: approved


DESCRIPTION:
Fleroxacin is a broad-spectrum antimicrobial fluoroquinolone. It strongly inhibits the DNA-supercoiling activity of DNA gyrase.

VOLUME OF DISTRIBUTION: Not Available

CATEGORIES:
Anti-Infective Agents Anti-Infectives Quinolones Nucleic Acid Synthesis Inhibitors

ABSORPTION: Rapidly and well absorbed from the gastrointestinal tract after oral administration.

INDICATION:
Fleroxacin is a broad-spectrum antimicrobial fluoroquinolone.

PHARMACODYNAMICS:
Fleroxacin is a broad-spectrum antimicrobial fluoroquinolone. It strongly inhibits the DNA-supercoiling activity of DNA gyrase.

MECHANISM OF ACTION:
The inhibition of DNA gyrase and DNA topoisomerase 2 leads ultimately to cell death as these enzymes are required for bacterial DNA replication, transcription, repair, strand supercoiling repair, and recombination.

PROTEIN BINDING:
Not Available

TOXICITY:
Not Available

AFECTED ORGANISMS:
Not Available