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Novobiocin


ACCESSION NB: DB01051 (APRD00694)


TYPE: small molecule


GROUP: approved


DESCRIPTION:
An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189) [PubChem]

CATEGORIES:
Anti-Bacterial Agents Enzyme Inhibitors Nucleic Acid Synthesis Inhibitors

ABSORPTION: Oral bioavailability is negligible.

INDICATION:
For the treatment of infections due to staphylococci and other susceptible organisms

PHARMACODYNAMICS:
Novobiocin is an aminocoumarin antibiotic that was produced by the actinomycete Streptomyces niveus. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. Other antibiotics in the aminocoumarin class include coumermycin A1 and clorobiocin.

MECHANISM OF ACTION:
Novobiocin is an aminocoumarin. Aminocoumarins are very potent inhibitors of bacterial DNA gyrase and work by inhibiting the GyrB subunit of the enzyme involved in energy tranduction. Novobiocin as well as the other aminocoumarin antibiotics act as competitive inhibitors of the ATPase reaction catalysed by GyrB.

PROTEIN BINDING:
95%

AFECTED ORGANISMS:
Enteric bacteria and other eubacteria