Please note: Any medical or genetic information present in this entry is not intended as a diagnosis of your problem, but rather is provided as a helpful guide for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Information is not necessarily complete. Please see your doctor for diagnosis and treatment.

Please note: DNAtraffic database is the project under construction and information on this page is not finished yet.

Uracil mustard


ACCESSION NB: DB00791 (APRD00130)


TYPE: small molecule


GROUP: approved


DESCRIPTION:
Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage. [PubChem]

CATEGORIES:
Antineoplastic Agents Antineoplastic Agents, Alkylating

INDICATION:
Used for its antineoplastic properties.

PHARMACODYNAMICS:
Uracil Mustard selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Uracil Mustard-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.

MECHANISM OF ACTION:
After activation, it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function.

PROTEIN BINDING:
5%

AFECTED ORGANISMS:
Humans and other mammals