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Podofilox


ACCESSION NB: DB01179 (APRD01189)


TYPE: small molecule


GROUP: approved


DESCRIPTION:
A lignan (lignans) found in podophyllin resin from the roots of podophyllum plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives. [PubChem]

VOLUME OF DISTRIBUTION: Not Available

CATEGORIES:
Keratolytic Agents, Antineoplastic Agents, Phytogenic Antimitotic agent Tubulin Modulators

ABSORPTION: Topical application of 0.05 mL of 0.5% podofilox solution to external genitalia did not result in detectable serum levels. Applications of 0.1 to 1.5 mL resulted in peak serum levels of 1 to 17 ng/mL one to two hours after application.

INDICATION:
For treatment of external genital warts (Condyloma acuminatum).

PHARMACODYNAMICS:
Podofilox, also called podophyllotoxin, is a purer and more stable form of podophyllin in which only the biologically active portion of the compound is present. Podofilox is used to remove certain types of warts on the outside skin of the genital areas.

MECHANISM OF ACTION:
The exact mechanism of action is not well understood. It does appear, however, that it and its derivatives may bind and inhibit topoisomerase II during the late S and early G2 stage. The drug may bind and stabilize the temporary break caused by the enzyme. This disrupts the reparation of the break through which the double-stranded DNA passes, and consequently stops DNA unwinding and replication.

PROTEIN BINDING:
Not Available

TOXICITY:
Not Available

AFECTED ORGANISMS:
Condyloma acuminatum