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2'3'-Dideoxyinosine


ACCESSION NB: DB02392 (EXPT00112)


TYPE: small molecule


GROUP: experimental


DESCRIPTION:
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite. [PubChem]

CATEGORIES:
Anti-HIV Agents Antimetabolites Reverse Transcriptase Inhibitors Purine Nucleoside Phosphorylase inhibitor