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Chloroxine


ACCESSION NB: DB01243 (APRD00866)


TYPE: small molecule


GROUP: approved


DESCRIPTION:
Chloroxine is a synthetic antibacterial compound. Chloroxine is a compound used in some shampoos for the treatment of dandruff and seborrheic dermatitis of the scalp.

VOLUME OF DISTRIBUTION: Not Available

CATEGORIES:
Antiseborrheic

ABSORPTION: Not Available

INDICATION:
Used in the treatment of dandruff and mild to moderately severe seborrheic dermatitis of the scalp.

PHARMACODYNAMICS:
Chloroxine has an antibacterial action, inhibiting the growth of gram-positive as well as some gram-negative organisms. Also, chloroxine has shown some antifungal activity against certain dermatophytes and yeasts.

MECHANISM OF ACTION:
Although the mechanism of action is not understood, chloroxine may slow down mitotic activity in the epidermis, thereby reducing excessive scaling associated with dandruff or seborrheic dermatitis of the scalp. Chloroxine induces SOS-DNA repair in E. coli, so chloroxine may be genotoxic to bacteria.

PROTEIN BINDING:
Not Available

TOXICITY:
The toxicological properties of this material have not been investigated.

AFECTED ORGANISMS:
Humans and other mammals