Blood cell cancer

Cancer develops when cells in the body multiply out of control. Blood contains three kinds of cells: red cells, white cells and platelets. Any of these kinds of cells can develop into cancer cells.
Multiple myeloma is a blood cell (plasma cell) cancer most often diagnosed in people over the age of 65. In the United States, the risk of multiple myeloma is highest among African-Americans and lowest among Asian-Americans. It is estimated that this cancer affects five to six individuals per 100,000 each year. In multiple myeloma, the bone marrow produces excessive amounts of abnormal plasma cells. Unlike other cancers where there is always a tumor, these cancer cells are most often in the bone marrow and in the blood throughout the body, although a tumor can form in the bone or in soft tissues.
Waldenstrom’s macroglobulinemia is a blood cell cancer. White blood cells called B lymphocytes multiply out of control, invading the bone marrow, liver, and spleen. People over age 50 have the highest risk for this type of cancer. It is estimated that about 1,000 to 1,500 people are diagnosed each year with Waldenstrom’s macroglobulinemia in the United States. White males develop this cancer twice as often as black males or white or black females. Waldenstrom’s macroglobulinemia is somewhat similar to two other types of cancer, multiple myeloma (plasma cell cancer) and non-Hodgkin's lymphoma (a group of cancers of lymphocytes). The cancerous B lymphocytes in Waldenstrom’s macroglobulinemia produce excessive amounts of an antibody protein called immunoglobulin M (IgM). This makes the blood thick (hyperviscous), which affects the blood flow through smaller blood vessels to the organs of the body. This causes most of the symptoms of the disease, including nervous system, heart, and vision problems.
Leukemia is a cancer of white blood cells. The white blood cells divide and multiply out of control, forming cancerous blast cells. Leukemia can progress quickly (acute) or slowly (chronic). Leukemia including the four major types of leukemia- Acute Myelogenous Leukemia (AML), Chronic Myelogenous Leukemia (CML), Acute Lymphocytic Leukemia (ALL), and Chronic Lymphocytic Leukemia (CLL).
Lymphoma is not a single cancer but a group of many related cancers. In fact, there are nearly 30 different types of lymphoma. Broadly, they are grouped under two categories: Hodgkin Disease and Non-Hodgkin Lymphoma. These two broad groups may be similar in their symptoms and the tests that are required, but they behave differently when they affect a person.

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OMIM ID NAME PROTEINS TYPE ALIASES ABBREVIATIONS PATHWAY(S) RELATED
608232 chronic myeloid leukemia (CML) CANCER, blood cell cancer CHRONIC MYELOGENOUS LEUKEMIA
chronic granulocytic leukemia (CGL)
CML
CGL
xxx6 mantle cell lymphoma ATM blood cell cancer MCL DNA damage response (DDR)
208900 ataxia-telangiectasia (AT) ATM neurodegenerative disease, blood cell cancer, psychomotor impairment, skeletal abnormalities, risk of malignant disease, chromosomal instability, immunodeficiency, sexual immaturity, sensitivity to radiation, CANCER, eye or vision problem Louis-Bar syndrome
AT, COMPLEMENTATION GROUP A, INCLUDED; ATA, INCLUDED
Boder-Sedgwick syndrome
AT
AT1
DNA damage response (DDR)
254500 multiple myeloma (AL), resistance to LIG4 blood cell cancer, chromosomal instability, immunodeficiency SYSTEMIC AMYLOIDOSIS
AL AMYLOIDOSIS
AL non-homologous end-joining (NHEJ)
xxx7 B-cell acute lymphoblastic leukemia (B-ALL) DNTT (TdT), MLL, TET1 blood cell cancer Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) B-ALL
BALL
histone modification, non-homologous end-joining (NHEJ)
xxx5 T-cell acute lymphoblastic leukemia (T-ALL) ATM, DNTT (TdT), MLL, TET1 blood cell cancer Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) T-ALL
TALL
DNA damage response (DDR), histone modification, non-homologous end-joining (NHEJ)
127550 dyskeratosis congenita autosomal dominant (ADDKC) TERT (telomerase catalytic subunit), DKC1 blood cell cancer, risk of malignant disease, skin problem, bone marrow failure dyskeratosis congenita Scoggins type telomere maintenance
xxx4 T-cell-prolymphocytic leukemia (T-PLL) ATM risk of malignant disease, CANCER, blood cell cancer T-cell chronic lymphocytic leukemia
"knobby" type of T-cell leukemia
T-prolymphocytic leukemia
T-cell lymphocytic leukemia
T-PLL
TPLL
DNA damage response (DDR)
xxx B-cell non-Hodgkin lymphomas (B-NHL) ATM CANCER, blood cell cancer B-NHL
NHL
BNHL
DNA damage response (DDR)
276300 mismatch repair cancer syndrome (MMRCS) MSH2, MLH1, MSH6, PMS2 nervous system (NS) cancer, gastrointestinal (GI) cancer, blood cell cancer, risk of malignant disease, CANCER Turcot syndrome
brain tumor-polyposis syndrome 1
MMR DEFICIENCY
CHILDHOOD CANCER SYNDROM
BTP1 SYNDROME
MMRCS
BTPS1
Fanconi anemia (FA) pathway, mismatch repair (MMR)
605724 Fanconi anemia, complementation group D1 (FANCD1) BRCA2 (FANCD1) blood cell cancer, skeletal abnormalities, risk of malignant disease, skin problem, chromosomal instability Fanconi D1 FANCD1
FAD1
Fanconi anemia (FA) pathway, homologous recombination (HR)
612555 breast-ovarian cancer familial type 2 (BROVCA2) BRCA2 (FANCD1) blood cell cancer, risk of malignant disease, CANCER, breast cancer Fanconi anemia group D1 protein BROVCA2 Fanconi anemia (FA) pathway, homologous recombination (HR)
none T-cell non-Hodgkin lymphomas (T-NHL) blood cell cancer T-NHL
NHL
TNHL
none B-cell chronic lymphocytic leukemia (B-CLL) ATM blood cell cancer B-CLL
CLL
BCLL
DNA damage response (DDR)

Last modification date: July 1, 2011