Skin cancer

Skin neoplasms are skin growths with differing causes and varying degrees of malignancy. The three most common malignant skin cancers are basal cell cancer, squamous cell cancer, and melanoma, each of which is named after the type of skin cell from which it arises. Skin cancer generally develops in the epidermis (the outermost layer of skin), so a tumor can usually be seen. This means that it is often possible to detect skin cancers at an early stage. Skin cancer is the most commonly diagnosed type of cancer. Melanoma and non-melanoma skin cancers combined are more common than lung, breast, colorectal, and prostate cancer. Melanoma is less common than both basal cell carcinoma and squamous cell carcinoma, but it is the most serious.

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OMIM ID NAME PROTEINS TYPE ALIASES ABBREVIATIONS PATHWAY(S) RELATED
278780 xeroderma pigmentosum, complementation group G (XPG) ERCC5 (XPG) microcephaly, neurodegenerative disease, mental retardation (MR), risk of malignant disease, skin problem, sensitivity to radiation, CANCER, skin cancer xeroderma pigmentosum VII XPG
XP7
nucleotide excision repair (NER)
278700 xeroderma pigmentosum, complementation group A (XPA) XPA neurodegenerative disease, skin problem, sensitivity to radiation, skin cancer XERODERMA PIGMENTOSUM I
XP, GROUP A
XPA
XP1
nucleotide excision repair (NER)
158320 Muir-Torre syndrome MSH2, MLH1 skin cancer, CANCER CUTANEOUS SEBACEOUS NEOPLASMS AND KERATOACANTHOMAS, MULTIPLE, WITH GASTROINTESTINAL AND OTHER CARCINOMAS MuToS
MTS
MRTES
Fanconi anemia (FA) pathway, mismatch repair (MMR)
278720 xeroderma pigmentosum, complementation group C (XPC) XPC risk of malignant disease, skin problem, sensitivity to radiation, CANCER, skin cancer XERODERMA PIGMENTOSUM III
XP, GROUP C
XPC
XPCC
XP3
nucleotide excision repair (NER)
610651 xeroderma pigmentosum, complementation group B (XPB) ERCC3 (XPB) sensitivity to radiation, skin cancer XPB
XPBC
nucleotide excision repair (NER), transcription factors

Last modification date: Aug. 20, 2011