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B-cell acute lymphoblastic leukemia (B-ALL)

KEGG ds:H00001

Acute lymphoblastic leukaemia (ALL), a malignant disorder of lymphoid progenitor cells, affects both children and adults, with peak prevalence between the ages of 2 and 5 years. ALL arises from recurrent genetic insults that block precursor B and T cell differentiation and drive aberrant cell proliferation and survival. Recurrent defects generate molecular subgroups of B- and T-ALL. B-precursor ALL is the most common form of acute leukemia in children. The t(12;21) translocation that creates the TEL-AML1 fusion gene is the most common genetic lesion in pediatric ALL, occurring in 20-25% of B-lineage cases, but is much less common in adult ALL. Conversely, unlike adult B-ALL, in which t(9;22) is identified in approximately 33% of cases, this translocation encoding the BCR-ABL fusion protein is found in only 5% of childhood cases.

OTHER NAME(S): Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)

ABREVIATION(S):
B-ALL
BALL

TYPE: blood cell cancer

Related patway(s): histone modification, non-homologous end-joining (NHEJ)

DNAtraffic protein(s) related to disease: DNTT (TdT), MLL, TET1

OMIM: xxx7

Last modification date: July 6, 2011