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pancreatic cancer, susceptibility to, 3

Defects in PALB2 (FANCN) are the cause of pancreatic cancer type 3 (PNCA3) [MIM:613348]. It is a malignant neoplasm of the pancreas. Tumors can arise from both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue.

TYPE: CANCER

Related patway(s): Fanconi anemia (FA) pathway

DNAtraffic protein(s) related to disease: FANCN (PALB2)

OMIM: 613348

Last modification date: Aug. 24, 2011