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T-cell acute lymphoblastic leukemia (T-ALL)

T-cell acute lymphoblastic leukemia accounts for about 15% and 25% of ALL in pediatric and adult cohorts respectively. Patients usually have high white blood cell counts and may present with organomegaly, particularly mediastinal enlargement and CNS involvement. The biological knowledge of TALL has until recently been rather limited.

Cancer of particular white blood cells called T-cells. Precursors to white blood cells are called blasts and are made by the bone marrow but in ALL the blasts are abnormal and do not develop into lymphocytes. Instead, the abnormal blasts or leukemic cells multiply rapidly and reduce the level of other types of blood cells such as red blood cells and platelets.

KEGG: ds:H00002

OTHER NAME(S): Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)

ABREVIATION(S):
T-ALL
TALL

TYPE: blood cell cancer

Related patway(s): DNA damage response (DDR), histone modification, non-homologous end-joining (NHEJ)

DNAtraffic protein(s) related to disease: ATM, DNTT (TdT), MLL, TET1

OMIM: xxx5

Last modification date: July 6, 2011