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T-cell-prolymphocytic leukemia (T-PLL)

T-cell-prolymphocytic leukemia is a mature T-cell leukemia with aggressive behavior and predilection for blood, bone marrow, lymph nodes, liver, spleen, and skin involvement. T-cell prolymphocytic leukemia is a rare form of T-cell leukemia (a subtype of chronic lymphocytic leukemia (CLL)). Affecting only 2% of all adult small lymphocytic leukemia patients, it is a chemotherapy-resistant, aggressive cancer unique to adults over the age of 30.

OTHER NAME(S): T-cell chronic lymphocytic leukemia
"knobby" type of T-cell leukemia
T-prolymphocytic leukemia
T-cell lymphocytic leukemia

ABREVIATION(S):
T-PLL
TPLL

TYPE: risk of malignant disease, CANCER, blood cell cancer

Related patway(s): DNA damage response (DDR)

DNAtraffic protein(s) related to disease: ATM

OMIM: xxx4

Last modification date: July 30, 2011