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Li-Fraumeni syndrome-2

Is a highly penetrante familial cancer phenotype usually associated with inherited mutations in p53/TP53.


TYPE: risk of malignant disease, CANCER

Related patway(s): DNA damage response (DDR)

DNAtraffic protein(s) related to disease: CHEK2 (CHK2), TP53

OMIM: 609265

Last modification date: Nov. 26, 2012