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xeroderma pigmentosum, complementation group A (XPA)

Xeroderma pigmentosum (XP) is an autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. 
XP-A is a rare human autosomal recessive disease characterized by solar sensitivity, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. Group A patients show the most severe skin symptoms and progressive neurological disorders.

OTHER NAME(S): XERODERMA PIGMENTOSUM I
XP, GROUP A

ABREVIATION(S):
XPA
XP1

TYPE: neurodegenerative disease, skin problem, sensitivity to radiation, skin cancer

Related patway(s): nucleotide excision repair (NER)

DNAtraffic protein(s) related to disease: XPA

OMIM: 278700

Last modification date: Aug. 17, 2011