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gastric cancer hereditary diffuse (GCDH)

A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.

OTHER NAME(S): GASTRIC CANCER, FAMILIAL DIFFUSE

ABREVIATION(S):
GCDH
GASC

TYPE: gastrointestinal (GI) cancer

Related patway(s): base excision repair (BER)

DNAtraffic protein(s) related to disease: MUTYH

OMIM: 137215

Last modification date: Aug. 25, 2011