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systemic lupus erythematosus (SLE)

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease (or autoimmune connective tissue disease) that can affect any part of the body. As occurs in other autoimmune diseases, the immune system attacks the body's cells and tissue, resulting in inflammation and tissue damage. It is a Type III hypersensitivity reaction caused by antibody-immune complex formation.

SLE is a chronic autoimmune disease where the immune system is over-active and produces too many abnormal antibodies that react with the patient's own tissues. The exact cause of lupus is not known, but heredity, environment and hormonal changes may be involved. The immune complex deposition in many tissues leads to the manifestations of the disease. SLE most often harms the heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system. The course of the disease is unpredictable, with periods of illness (called flares) alternating with remissions. The disease occurs nine times more often in women than in men, especially in women in child-bearing years ages 15 to 35, and is also more common in those of non-European descent. Many SLE patients develop renal complications.

OTHER NAME(S): lupus
lupus erythematosus
EXCESS LYMPHOCYTE LOW MOLECULAR WEIGHT DNA, INCLUDED
EXCESS LMW-DNA, INCLUDED

ABREVIATION(S):
SLE

TYPE: immunodeficiency

Related patway(s): non-homologous end-joining (NHEJ)

DNAtraffic protein(s) related to disease: Ku70 (XRCC6), Ku80 (XRCC5)

OMIM: 152700

Last modification date: Feb. 6, 2012