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breast-ovarian cancer familial type 1 (BROVCA1)

A condition associated with familial predisposition to cancer of the breast and ovaries. Characteristic features in affected families are an early age of onset of breast cancer (often before age 50), increased chance of bilateral cancers (cancer that develop in both breasts, or both ovaries, independently), frequent occurrence of breast cancer among men, increased incidence of tumors of other specific organs, such as the prostate.
Mutations in BRCA1 are thought to be responsible for more than 80% of inherited breast-ovarian cancer.

OTHER NAME(S): BREAST-OVARIAN CANCER 1, FAMILIAL, SUSCEPTIBILITY
BREAST CANCER 1, FAMILIAL, SUSCEPTIBILITY
OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1

ABREVIATION(S):
BROVCA1

TYPE: breast cancer, CANCER

Related patway(s): Fanconi anemia (FA) pathway

DNAtraffic protein(s) related to disease: BRCA1

OMIM: 604370

Last modification date: Aug. 21, 2011