benzene


DESCRIPTION: Benzene is an organic chemical compound. It is composed of 6 carbon atoms in a ring, with 1 hydrogen atom attached to each carbon atom, with the molecular formula C6H6.
Benzene causes cancer and other illnesses. Benzene is a "notorious cause" of bone marrow failure. "Vast quantities of epidemiologic, clinical, and laboratory data" link benzene to aplastic anemia, acute leukemia, and bone marrow abnormalities.
The major effects of benzene are manifested via chronic (long-term) exposure through the blood. Benzene damages the bone marrow and can cause a decrease in red blood cells, leading to anemia. It can also cause excessive bleeding and depress the immune system, increasing the chance of infection. Benzene causes leukemia and is associated with other blood cancers and pre-cancers of the blood.

DNA DAMAGES:
p-BQ-A
p-BQ-C
p-BQ-G


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NAME STRUCTURE PROTEINS DNA DAMAGE EFFECT(S) PATHWAY(S) RELATED
p-BQ-A UvrC
UvrB
ERCC5 (XPG)
ERCC4 (XPF)
carcinogen
cytotoxic
DNA backbone distortion
stalled replication fork
Fanconi anemia (FA) pathway
nucleotide excision repair (NER)
prokaryotic (SOS) response
p-BQ-C UvrC
UvrB
ERCC5 (XPG)
ERCC4 (XPF)
carcinogen
cell cycle arrest
cytotoxic
DNA backbone distortion
stalled replication fork
Fanconi anemia (FA) pathway
nucleotide excision repair (NER)
prokaryotic (SOS) response
p-BQ-G UvrC
UvrB
ERCC5 (XPG)
ERCC4 (XPF)
carcinogen Fanconi anemia (FA) pathway
nucleotide excision repair (NER)
prokaryotic (SOS) response

Last modification date: Oct. 1, 2011