repair intermediate


OTHER NAMES:
repair enzyme activity
dirty ends


DESCRIPTION: DNA termini undergo attachment and dissociation of repair enzymes. Step-by-step removal of nearby base lesions and strand breaks is considered for dirty DNA ends.

DNA DAMAGES:
AP-site
5'-AMP end
3'-TOP1 termini
3'-OH end
5'-P end
5'-TOP2 termini
3'-P
3'-PUA termini
5'-dRP termini


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NAME STRUCTURE PROTEINS DNA DAMAGE EFFECT(S) PATHWAY(S) RELATED
AP-site Nfo (endo IV)
APEX1
APEX2
XthA (exo III)
TDP1
UvrC
UvrB
DDB2 (XPE)
-1 frameshift
cytotoxic
mutagenesis
nucleotide incision repair (NIR)
base excision repair (BER)
nucleotide excision repair (NER)
prokaryotic (SOS) response
5'-AMP end APTX cell cycle arrest
cytotoxic
3'-TOP1 termini TDP1 apoptosis
cytotoxic
base excision repair (BER)
3'-OH end XthA (exo III)
Nfo (endo IV)
APEX1
APEX2
DnaQ
TREX2
TREX1 (DNase III)
apoptosis
cell cycle arrest
DNA replication
base excision repair (BER)
mismatch repair (MMR)
homologous recombination (HR)
Fanconi anemia (FA) pathway
nucleotide incision repair (NIR)
5'-P end RecJ
FEN1 (DNase IV)
DNA Pol I
cell cycle arrest DNA replication
base excision repair (BER)
nucleotide excision repair (NER)
mismatch repair (MMR)
homologous recombination (HR)
non-homologous end-joining (NHEJ)
5'-TOP2 termini TDP2 cell cycle arrest
cytotoxic
3'-P APTX
APEX1
XthA (exo III)
Nfo (endo IV)
APEX2
PNKP (PNK)
cell cycle arrest
cytotoxic
nucleotide incision repair (NIR)
base excision repair (BER)
3'-PUA termini XthA (exo III)
Nfo (endo IV)
Fpg (MutM)
Nei (endo VIII)
APTX
APEX1
APEX2
cytotoxic
stalled replication fork
nucleotide incision repair (NIR)
base excision repair (BER)
5'-dRP termini FEN1 (DNase IV)
POLβ (POLB)
DNA Pol I
RecJ
HMGB1
POLγ (POLG)
POLλ (POLL)
cytotoxic DNA replication
base excision repair (BER)
nucleotide excision repair (NER)
mismatch repair (MMR)
homologous recombination (HR)
non-homologous end-joining (NHEJ)
translesion synthesis (TLS)

Last modification date: Oct. 3, 2011