streptozotocin


OTHER NAMES:
streptozocin
Zanosar
2-deoxy-D-glucose derivative of MNU


ABBREVIATIONS:
STZ


DESCRIPTION: Streptozotocin is a naturally occurring antibiotic produced by the soil bacterium Streptomyces achromogenes, is a 2-deoxy-D-glucose derivative of MNU. S.achromogenes is itself resistant to the compound, which has a toxicity that apparently profits the bacterium in competition with other soil organisms.

Streptozotocin is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. It is used in medicine for treating certain cancers of the Islets of Langerhans and used in medical research to produce an animal model for Type 1 diabetes.

DNA DAMAGES:
3-methyl A (3meA)
N7-methyl G (7meG)
3-methyl A (3-meA) in ssDNA


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NAME STRUCTURE PROTEINS DNA DAMAGE EFFECT(S) PATHWAY(S) RELATED
3-methyl A (3meA) AlkA
Tag
ANPG (MPG)
AP-site
A→T transversion
cell cycle arrest
cytotoxic
mutagenesis
point mutation
stalled replication fork
base excision repair (BER)
N7-methyl G (7meG) AlkA
Fpg (MutM)
Tag
ANPG (MPG)
no mutagenesis base excision repair (BER)
3-methyl A (3-meA) in ssDNA AlkA AP-site
A→T transversion
cell cycle arrest
cytotoxic
mutagenesis
point mutation
stalled replication fork
transversion
base excision repair (BER)

Last modification date: Aug. 14, 2011