ethyl methanesulfonate (EMS)


ABBREVIATIONS:
EMS


DESCRIPTION: Is an alkylating (ethylating) agent (SN2 type).

DNA DAMAGES:
1-ethyl A (1etA)
3-ethyl C (3etC)
O6-ethyl G (O6etG)


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NAME STRUCTURE PROTEINS DNA DAMAGE EFFECT(S) PATHWAY(S) RELATED
1-ethyl A (1etA) ALKBH2
AlkB
ALKBH3
cytotoxic
stalled replication fork
direct reversal (DR)
3-ethyl C (3etC) AlkB C→T transition
cytotoxic
mutagenesis
point mutation
stalled replication fork
substitution
transition
direct reversal (DR)
O6-ethyl G (O6etG) MGMT cytotoxic direct reversal (DR)

Last modification date: Aug. 28, 2011