DNA methyltransferase


OTHER NAMES:
methyltransferase


ABBREVIATIONS:
DNA MTase


DESCRIPTION: The DNA methyltransferase DNA MTas) family of enzymes catalyze the transfer of a methyl group to DNA. DNA methylation serves a wide variety of biological functions. All the known DNA methyltransferases use S-adenosyl methionine (SAM) as the methyl donor.

MTases can be divided into three different groups on the basis of the chemical reactions they catalyze:
- m6A - those that generate N6-methyladenine EC 2.1.1.72
- m4C - those that generate N4-methylcytosine EC 2.1.1.113
- m5C - those that generate C5-methylcytosine EC 2.1.1.37

m6A and m4C methyltransferases are found primarily in prokaryotes. m5C methyltransfereases are found in some lower eukaryotes, in most higher plants, and in animals beginning with the echinoderms.

DNA DAMAGES:
5-methyl C (5meC)
N,4-methyl C in 5'-CAGCTG-3'


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NAME STRUCTURE PROTEINS DNA DAMAGE EFFECT(S) PATHWAY(S) RELATED
5-methyl C (5meC) no mutagenesis
N,4-methyl C in 5'-CAGCTG-3' no mutagenesis

Last modification date: Aug. 13, 2011