lipid peroxidation (LPO)


ABBREVIATIONS:
LPO


DESCRIPTION: Lipid peroxidation refers to the oxidative degradation of lipids. It is the process in which free radicals "steal" electrons from the lipids in cell membranes, resulting in cell damage. This process proceeds by a free radical chain reaction mechanism. It most often affects polyunsaturated fatty acids, because they contain multiple double bonds in between which lie methylene -CH2- groups that possess especially reactive hydrogens. As with any radical reaction, the reaction consists of three major steps: initiation, propagation, and termination.
Initiation is the step in which a fatty acid radical is produced. The most notable initiators in living cells are reactive oxygen species (ROS), such as OH· and HO2, which combines with a hydrogen atom to make water and a fatty acid radical.

DNA DAMAGES:
1,N2-beta-OH-ethano G (HEG)
M1A (OPA)
M1dG
N2-OH-propyl-G (hpG)
1,N2-etheno-G (1,2εG) in dsDNA
1,N6-etheno-A (1εA)
1,N2-gamma-hydroxypropano-G (HPG)
1,N6-alpha-hydroxyethano-A (HEA)
3,N4-hydroxypropyl-C (HPC)
1,N2-etheno-G (εG) in ssDNA
1,N2-alpha-hydroxypropano-G (HPG)
N2,3-etheno-G (N2,3-εG)
1,N2-propano-G (PG)
1-OH-propyl-G (hpG)
1,N6-etheno-A in (1εA) dsDNA
M3C
3,N4-alpha-OH-gamma-methyl-propano-C (mHPC)
M3dA
3,N4-ethano-C (EC)
1,N2-alpha-methyl-gamma-OH-propano-G (mHPG)
M1C (OPC)
1,N6-etheno-A (1εA) in ssDNA
1,N6-alpha-hydroxypropano-A (HPA)
M2G


Filter

Click on a column header name to sort

NAME STRUCTURE PROTEINS DNA DAMAGE EFFECT(S) PATHWAY(S) RELATED
1,N2-beta-OH-ethano G (HEG) mutagenesis
stalled replication fork
M1A (OPA) UvrC
UvrB
ERCC5 (XPG)
ERCC4 (XPF)
A→G transition
carcinogen
mutagenesis
transition
Fanconi anemia (FA) pathway
nucleotide excision repair (NER)
prokaryotic (SOS) response
M1dG UvrC
UvrB
ERCC5 (XPG)
ERCC4 (XPF)
carcinogen
G→A transition
G→C transversion
G→T transversion
mutagenesis
point mutation
substitution
transition
transversion
Fanconi anemia (FA) pathway
nucleotide excision repair (NER)
prokaryotic (SOS) response
N2-OH-propyl-G (hpG) mutagenesis
point mutation
1,N2-etheno-G (1,2εG) in dsDNA Mug
ANPG (MPG)
Mug
-1 frameshift
deletion
G→C transversion
G→T transversion
mutagenesis
point mutation
stalled replication fork
transversion
base excision repair (BER)
1,N6-etheno-A (1εA) AlkA
Fpg (MutM)
ANPG (MPG)
AlkB
ALKBH2
A→T transversion
mutagenesis
point mutation
transversion
base excision repair (BER)
direct reversal (DR)
1,N2-gamma-hydroxypropano-G (HPG) carcinogen
cytotoxic
DNA backbone distortion
mutagenesis
stalled replication fork
1,N6-alpha-hydroxyethano-A (HEA) cell cycle arrest
DNA backbone distortion
mutagenesis
stalled replication fork
3,N4-hydroxypropyl-C (HPC) Mug DNA backbone distortion
stalled replication fork
base excision repair (BER)
1,N2-etheno-G (εG) in ssDNA ALKBH2 deletion
G→C transversion
G→T transversion
mutagenesis
point mutation
stalled replication fork
substitution
transversion
direct reversal (DR)
1,N2-alpha-hydroxypropano-G (HPG) carcinogen
cytotoxic
DNA backbone distortion
stalled replication fork
N2,3-etheno-G (N2,3-εG) AlkA G→A transition
mutagenesis
point mutation
substitution
transition
base excision repair (BER)
1,N2-propano-G (PG) cell cycle arrest
stalled replication fork
1-OH-propyl-G (hpG) mutagenesis
point mutation
1,N6-etheno-A in (1εA) dsDNA AlkA
Fpg (MutM)
ANPG (MPG)
AlkB
mutagenesis
point mutation
substitution
transition
transversion
base excision repair (BER)
direct reversal (DR)
M3C UvrC
UvrB
ERCC5 (XPG)
ERCC4 (XPF)
carcinogen
mutagenesis
Fanconi anemia (FA) pathway
nucleotide excision repair (NER)
prokaryotic (SOS) response
3,N4-alpha-OH-gamma-methyl-propano-C (mHPC) Mug carcinogen
cell cycle arrest
cytotoxic
DNA backbone distortion
stalled replication fork
base excision repair (BER)
M3dA UvrC
UvrB
ERCC5 (XPG)
ERCC4 (XPF)
carcinogen
mutagenesis
Fanconi anemia (FA) pathway
nucleotide excision repair (NER)
prokaryotic (SOS) response
3,N4-ethano-C (EC) AlkA mutagenesis
point mutation
substitution
base excision repair (BER)
1,N2-alpha-methyl-gamma-OH-propano-G (mHPG) UvrC
UvrB
carcinogen
cytotoxic
DNA backbone distortion
stalled replication fork
nucleotide excision repair (NER)
prokaryotic (SOS) response
M1C (OPC) UvrC
UvrB
ERCC5 (XPG)
ERCC4 (XPF)
carcinogen
C→T transition
mutagenesis
transition
Fanconi anemia (FA) pathway
nucleotide excision repair (NER)
prokaryotic (SOS) response
1,N6-etheno-A (1εA) in ssDNA ALKBH2 mutagenesis
point mutation
transition
transversion
direct reversal (DR)
1,N6-alpha-hydroxypropano-A (HPA) DNA backbone distortion
mutagenesis
stalled replication fork
M2G UvrC
UvrB
ERCC5 (XPG)
ERCC4 (XPF)
carcinogen
mutagenesis
Fanconi anemia (FA) pathway
nucleotide excision repair (NER)
prokaryotic (SOS) response

Last modification date: Aug. 20, 2011