crotonaldehyde (CRA)


OTHER NAMES:
(2E)-but-2-enal
crotoinic aldehyde
β-methacrolein


ABBREVIATIONS:
CRA


DESCRIPTION: Crotonaldehyde is a chemical compound with the formula CH3CH=CHCHO. The compound is usually sold as a mixture of the E- and Z-isomers, which differ with respect to the relative position of the methyl and formyl groups. The E-isomer is more common (data given in Table is for the E-isomer). This lachrymatory liquid is moderately soluble in water and miscible in organic solvents. As an unsaturated aldehyde, crotonaldehyde is a versatile intermediate in organic synthesis. It occurs in a variety of foodstuffs, e.g. soybean oils.

reactive keto-compounds

DNA DAMAGES:
3,N4-alpha-OH-gamma-methyl-propano-C (mHPC)
intErstrand crosslinks (ICLs)
1,N2-alpha-methyl-gamma-OH-propano-G (mHPG)


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NAME STRUCTURE PROTEINS DNA DAMAGE EFFECT(S) PATHWAY(S) RELATED
3,N4-alpha-OH-gamma-methyl-propano-C (mHPC) Mug carcinogen
cell cycle arrest
cytotoxic
DNA backbone distortion
stalled replication fork
base excision repair (BER)
intErstrand crosslinks (ICLs) UvrC
UvrB
ERCC5 (XPG)
ERCC4 (XPF)
MUS81
EME1
ERCC1
SLX4
SLX1A
SLX1B
TOP3A
cell cycle arrest
DNA backbone distortion
mutagenesis
stalled replication fork
Fanconi anemia (FA) pathway
nucleotide excision repair (NER)
prokaryotic (SOS) response
homologous recombination (HR)
DNA replication
1,N2-alpha-methyl-gamma-OH-propano-G (mHPG) UvrC
UvrB
carcinogen
cytotoxic
DNA backbone distortion
stalled replication fork
nucleotide excision repair (NER)
prokaryotic (SOS) response

Last modification date: Sept. 1, 2011