benzo(a)pyrene diol epoxide adduct


ABBREVIATIONS:
BPDE


DESCRIPTION: BPDE is the ultimate carcinogen formed by the metabolism of the polycyclic aromatic hydrocarbon (PAH), benzo[a]pyrene, which is found in cigarette smoke, burnt food and smoke from the burning of fossil fuels. BPDE binds mainly to guanines and is known to induce primarily GC→TA transversions.

DNA DAMAGES:
B[a]P-guanine


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NAME STRUCTURE PROTEINS DNA DAMAGE EFFECT(S) PATHWAY(S) RELATED
B[a]P-guanine UvrC
UvrB
ERCC5 (XPG)
ERCC4 (XPF)
-2 frameshift
mutagenesis
stalled replication fork
Fanconi anemia (FA) pathway
nucleotide excision repair (NER)
prokaryotic (SOS) response

Last modification date: Aug. 14, 2011