psoralen


OTHER NAMES:
psoralene
7H-furo[3,2-g]chromen-7-one
7H-furo[3,2-g][1]benzopyran-7-one


DESCRIPTION: Psoralen is the parent compound in a family of natural products known as furocoumarins. It is structurally related to coumarin by the addition of a fused furan ring, and may be considered as a derivative of umbelliferone. Psoralen occurs naturally in the seeds of Psoralea corylifolia, as well as in the common Fig, celery, parsley and West Indian satinwood. It is widely used in PUVA (=Psoralen +UVA) treatment for psoriasis, eczema, vitiligo, and cutaneous T-cell lymphoma. Many furocoumarins are extremely toxic to fish, and some are indeed used in streams in Indonesia to catch fish.

CHEBI:27616,
CHEMBL164660

DNA DAMAGES:
intErstrand crosslinks (ICLs)
DNA-psoralen
intrAstrand crosslink


Filter

Click on a column header name to sort

NAME STRUCTURE PROTEINS DNA DAMAGE EFFECT(S) PATHWAY(S) RELATED
intErstrand crosslinks (ICLs) UvrC
UvrB
ERCC5 (XPG)
ERCC4 (XPF)
MUS81
EME1
ERCC1
SLX4
SLX1A
SLX1B
TOP3A
cell cycle arrest
DNA backbone distortion
mutagenesis
stalled replication fork
Fanconi anemia (FA) pathway
nucleotide excision repair (NER)
prokaryotic (SOS) response
homologous recombination (HR)
DNA replication
DNA-psoralen UvrC
UvrB
NEIL1
cell cycle arrest
stalled replication fork
base excision repair (BER)
nucleotide excision repair (NER)
prokaryotic (SOS) response
intrAstrand crosslink UvrC
UvrB
ERCC5 (XPG)
ERCC4 (XPF)
cell cycle arrest
DNA backbone distortion
stalled replication fork
Fanconi anemia (FA) pathway
nucleotide excision repair (NER)
prokaryotic (SOS) response

Last modification date: Aug. 12, 2011