Damage effects

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DNA DAMAGE EFFECT DAMAGES
-1 frameshift AP-site
1,N2-etheno-G (1,2εG) in dsDNA
-2 frameshift B[a]P-guanine
A→C transversion 5-formyl dU from 5-formylU:G
1,N6-ethano A (EA)
5-formyl dU (5-foU)
1,N6-etheno-A (1εA)
A→G transition 5-formyl dU from 5-formylU:G
M1A (OPA)
1,N6-ethano A (EA)
5-bromoU
5-formyl dU (5-foU)
1,N6-etheno-A (1εA)
7-methyl A (7meA)
apoptosis 5'-TOP2 termini
3'-P
3'-TOP1 termini
5-hydroxymethyl U (5-OH-me-U)
3'-OH end
AP-site N7-methyl G (7meG)
aflatoxin-G
3-methyl A (3meA)
deoxyuridine
3-methyl A (3-meA) in ssDNA
A→T transversion 5-formyl dU from 5-formylU:G
5-formyl dU (5-foU)
3-methyl A (3meA)
1,N6-etheno-A (1εA)
1,N6-ethano A (EA)
N1-methyl A (1meA)
3-methyl A (3-meA) in ssDNA
carcinogen M1A (OPA)
p-BQ-A
M3C
aflatoxin-G
M1dG
3,N4-alpha-OH-gamma-methyl-propano-C (mHPC)
aflatoxin-FapyG
M3dA
1,N2-alpha-methyl-gamma-OH-propano-G (mHPG)
1,N2-gamma-hydroxypropano-G (HPG)
p-BQ-G
M1C (OPC)
1,N2-alpha-hydroxypropano-G (HPG)
p-BQ-C
M2G
C→A transversion 3,N4-ethenoC (εC) in ssDNA
3-ethyl C (3etC)
3,N4-etheno-C (εC) in dsDNA
8-oxoG
3-methyl C (3meC)
cell cycle arrest 5'-AMP end
5-bromoU
5-fluoroU from 5-fluoroU:G
5-fluoroU from 5-fluoroU:A
3-methyl A (3meA)
3,N4-alpha-OH-gamma-methyl-propano-C (mHPC)
DNA-psoralen
3'-OH end
p-BQ-G
1,N6-alpha-hydroxyethano-A (HEA)
5'-P end
5'-TOP2 termini
N3-methylT (3meT) in ssDNA
3'-P
1,N6-ethano A (EA)
1,N2-propano-G (PG)
p-BQ-C
intErstrand crosslinks (ICLs)
5-fluoro-dU
3-methyl A (3-meA) in ssDNA
intrAstrand crosslink
C→G transversion
C→T transition 5,6-dihydroxy C (5,6-diOH-C)
dU in dsDNA
dU in ssDNA
3,N4-ethenoC (εC) in ssDNA
3-ethyl C (3etC)
thymine glycol (Tg)
5-hydroxy C (5-OH-C)
deoxyuridine
3-methyl C (3meC)
cytosine glycol (Cg)
M1C (OPC)
5-hydroxy-6-hydro-C (5-OH-6-H-C)
cytotoxic AP-site
p-BQ-A
5-bromoU
5-fluoroU from 5-fluoroU:G
5-fluoroU from 5-fluoroU:A
aflatoxin-G
O6-ethyl G (O6etG)
N3-methyl T (3meT)
1,N2-gamma-hydroxypropano-G (HPG)
5'-TOP2 termini
1,N2-alpha-hydroxypropano-G (HPG)
p-BQ-C
O2-methyl T (O2meT)
5-fluoro-dU
3-methyl C (3meC)
O2-methyl C (O2meC)
MePT
O4-methyl T (O4meT)
N3-methyl G (3meG)
5'-AMP end
1-ethyl A (1etA)
3-methyl A (3meA)
3,N4-alpha-OH-gamma-methyl-propano-C (mHPC)
3-ethyl C (3etC)
3'-TOP1 termini
1,N2-alpha-methyl-gamma-OH-propano-G (mHPG)
3'-P
N1-methyl A (1meA)
3'-PUA termini
3-methyl A (3-meA) in ssDNA
5'-dRP termini
deletion 1,N2-etheno-G (1,2εG) in dsDNA
M1A (OPA)
1,N2-etheno-G (εG) in ssDNA
DNA backbone distortion 1,N6-etheno-A in (1εA) dsDNA
p-BQ-A
aflatoxin-G
3,N4-alpha-OH-gamma-methyl-propano-C (mHPC)
aflatoxin-FapyG
1,N6-etheno-A (1εA)
1,N2-alpha-methyl-gamma-OH-propano-G (mHPG)
1,N2-gamma-hydroxypropano-G (HPG)
p-BQ-G
1,N6-alpha-hydroxyethano-A (HEA)
3,N4-hydroxypropyl-C (HPC)
1,N6-etheno-A (1εA) in ssDNA
1,N6-alpha-hydroxypropano-A (HPA)
1,N2-alpha-hydroxypropano-G (HPG)
p-BQ-C
intErstrand crosslinks (ICLs)
intrAstrand crosslink
G→A transition 5-formyl dU from 5-formylU:G
5-bromoU
5-formyl dU (5-foU)
M1dG
5-hydroxy-U (5-OH-U)
O6-methyl G (O6meG)
O6-ethyl G (O6etG)
8-methyl G (8meG)
A:5-OH-U pair
G:5-OH-U pair
N2,3-etheno-G (N2,3-εG)
1-methyl G (1meG)
deoxyuridine
G→C transversion M1dG
1-methyl G (1meG)
1,N2-etheno-G (1,2εG) in dsDNA
8-methyl G (8meG)
1,N2-etheno-G (εG) in ssDNA
G→T transversion 5-formyl dU from 5-formylU:G
5-formyl dU (5-foU)
M1dG
1-methyl G (1meG)
1,N2-etheno-G (1,2εG) in dsDNA
8-oxoG
1,N2-etheno-G (εG) in ssDNA
insertion Tg from Tg:G
M1A (OPA)
M1dG
mutagenesis 1,N2-beta-OH-ethano G (HEG)
5-formyl dU from 5-formylU:G
T:5-OH-U pair
5-hydroxy-6-hydro-T (5-OH-6-H-T)
5-hydroxymethyl U (5-OH-me-U)
1-OH-propyl A (1hpA)
8-methyl G (8meG)
1,N2-etheno-G (εG) in ssDNA
1,N6-ethano A (EA)
FapyG from FapyG:C
A from A:G
3-methyl C (3meC)
5-OH-meU from 5-OH-meU:G
2-hydroxy-A (2-OH-A)
2-oxoA from 2-oxoA:G
3-propyl C (3pC)
O6-methyl G (O6meG)
Fapy-7meG from Fapy-7meG:C
1,N6-etheno-A (1εA) in ssDNA
7-methyl A (7meA)
AP-site
5,6-dihydroxy U (5,6-diOH-U)
5-formyl dU (5-foU)
3,N4-etheno-C (εC) in dsDNA
FapyA
8-oxoG
1,N6-alpha-hydroxyethano-A (HEA)
5-OH-meU from 5-OH-meU:A
dU in dsDNA
1,N2-alpha-hydroxypropano-G (HPG)
N2,3-etheno-G (N2,3-εG)
dU in ssDNA
p-BQ-C
thymine glycol (Tg)
1-OH-propyl-G (hpG)
8-oxoG from 8-oxoG:G
5-hydroxy-6-hydro-C (5-OH-6-H-C)
1-ethyl A (1etA)
1-propyl A (1pA)
M3C
3-methyl A (3meA)
3,N4-ethano-C (EC)
1,N2-alpha-methyl-gamma-OH-propano-G (mHPG)
M1C (OPC)
hypoxanthine in DNA
(6-4)PP
3,N4-ethenoC (εC) in ssDNA
1-methyl G (1meG)
3-methyl A (3-meA) in ssDNA
5-OH-meU in ssDNA
Tg from Tg:A
B[a]P-guanine
M1A (OPA)
M1dG
N2-OH-propyl-G (hpG)
8-oxoG from 8-oxoG:A
O6-ethyl G (O6etG)
1,N6-etheno-A (1εA)
A from A:C
dU from U:G
FapyG from FapyG:G
T from T:T
O4-methyl T (O4meT)
3-methylC (3meC) in RNA
FapyG:A
5,6-dihydro U (5,6-diH-U)
N3-methylT (3meT) in ssDNA
A:5-OH-U pair
5-hydroxy-6-hydro-U (5-OH-6-H-U)
5,6-dihydro T (5,6-diH-T)
intErstrand crosslinks (ICLs)
M2G
A from A:8-oxoG
p-BQ-A
5-bromoU
FapyG from FapyG:T
FapyG
5-hydroxy-U (5-OH-U)
1,N2-etheno-G (1,2εG) in dsDNA
N1-OH-ethyl A (1heA)
N3-methyl T (3meT)
1,N2-gamma-hydroxypropano-G (HPG)
8-oxoG from 8-oxoG:T
C:5-OH-U pair
5,6-dihydroxy C (5,6-diOH-C)
T from T:G
1,N6-etheno-A in (1εA) dsDNA
3,N4-alpha-OH-gamma-methyl-propano-C (mHPC)
3-ethyl C (3etC)
M3dA
1,N6-alpha-hydroxypropano-A (HPA)
N7-methyl G (7meG)
G:5-OH-U pair
uracil glycol (Ug)
2-oxoA
N1-methyl A (1meA)
3-methylC (3meC) in ssDNA
CPD
no mutagenesis 5-hydroxymethyl C
N7-methyl G (7meG)
A:5-OH-U pair
OEG
5-methyl C (5meC)
5-hydroxy-U (5-OH-U)
8-oxoG
N,4-methyl C in 5'-CAGCTG-3'
8-methyl G (8meG)
8-oxoG from 8-oxoG:C
dU from U:A
point mutation Tg from Tg:A
5-formyl dU from 5-formylU:G
T:5-OH-U pair
M1dG
N2-OH-propyl-G (hpG)
8-oxoG from 8-oxoG:A
5-hydroxy-6-hydro-T (5-OH-6-H-T)
O6-ethyl G (O6etG)
1,N6-etheno-A (1εA)
1-OH-propyl A (1hpA)
8-methyl G (8meG)
1,N2-etheno-G (εG) in ssDNA
1,N6-ethano A (EA)
A from A:C
dU from U:G
FapyG from FapyG:C
FapyG from FapyG:G
A from A:G
3-methyl C (3meC)
O4-methyl T (O4meT)
Tg from Tg:G
2-hydroxy-A (2-OH-A)
2-oxoA from 2-oxoA:G
FapyG:A
3-propyl C (3pC)
O6-methyl G (O6meG)
Fapy-7meG from Fapy-7meG:C
N3-methylT (3meT) in ssDNA
1,N6-etheno-A (1εA) in ssDNA
A:5-OH-U pair
7-methyl A (7meA)
A from A:8-oxoG
5-bromoU
FapyG from FapyG:T
5,6-dihydroxy U (5,6-diOH-U)
5-formyl dU (5-foU)
5-hydroxy-U (5-OH-U)
1,N2-etheno-G (1,2εG) in dsDNA
3,N4-etheno-C (εC) in dsDNA
N3-methyl T (3meT)
8-oxoG
dU in dsDNA
N2,3-etheno-G (N2,3-εG)
dU in ssDNA
8-oxoG from 8-oxoG:T
thymine glycol (Tg)
1-OH-propyl-G (hpG)
C:5-OH-U pair
8-oxoG from 8-oxoG:G
5-hydroxy-6-hydro-C (5-OH-6-H-C)
T from T:G
1,N6-etheno-A in (1εA) dsDNA
1-ethyl A (1etA)
1-propyl A (1pA)
3-methyl A (3meA)
3-ethyl C (3etC)
3,N4-ethano-C (EC)
N7-methyl G (7meG)
hypoxanthine in DNA
(6-4)PP
G:5-OH-U pair
3,N4-ethenoC (εC) in ssDNA
2-oxoA
1-methyl G (1meG)
N1-methyl A (1meA)
3-methyl A (3-meA) in ssDNA
CPD
stalled replication fork 1,N2-beta-OH-ethano G (HEG)
Tg from Tg:A
B[a]P-guanine
p-BQ-A
5-bromoU
5-fluoroU from 5-fluoroU:G
5-fluoroU from 5-fluoroU:A
aflatoxin-G
1,N2-etheno-G (1,2εG) in dsDNA
1,N6-etheno-A (1εA)
DNA-psoralen
3'-OH end
N3-methyl T (3meT)
1,N2-gamma-hydroxypropano-G (HPG)
1,N6-alpha-hydroxyethano-A (HEA)
8-methyl G (8meG)
3,N4-hydroxypropyl-C (HPC)
1,N2-etheno-G (εG) in ssDNA
1,N6-ethano A (EA)
1,N2-alpha-hydroxypropano-G (HPG)
FapyG from FapyG:C
1,N2-propano-G (PG)
p-BQ-C
thymine glycol (Tg)
5-fluoro-dU
intrAstrand crosslink
3-methyl C (3meC)
MePT
N3-methyl G (3meG)
Tg from Tg:G
1,N6-etheno-A in (1εA) dsDNA
1-ethyl A (1etA)
3-methyl A (3meA)
3,N4-alpha-OH-gamma-methyl-propano-C (mHPC)
aflatoxin-FapyG
3-ethyl C (3etC)
1,N2-alpha-methyl-gamma-OH-propano-G (mHPG)
Fapy-7meG from Fapy-7meG:C
N3-methylT (3meT) in ssDNA
1,N6-alpha-hydroxypropano-A (HPA)
(6-4)PP
uracil glycol (Ug)
N1-methyl A (1meA)
intErstrand crosslinks (ICLs)
3'-PUA termini
3-methyl A (3-meA) in ssDNA
CPD
substitution Tg from Tg:A
5-formyl dU from 5-formylU:G
M1dG
8-oxoG from 8-oxoG:A
8-methyl G (8meG)
1,N2-etheno-G (εG) in ssDNA
1,N6-ethano A (EA)
A from A:C
dU from U:G
FapyG from FapyG:C
A from A:G
O2-methyl T (O2meT)
3-methyl C (3meC)
O4-methyl T (O4meT)
Tg from Tg:G
2-oxoA from 2-oxoA:G
O6-methyl G (O6meG)
Fapy-7meG from Fapy-7meG:C
N3-methylT (3meT) in ssDNA
7-methyl A (7meA)
A from A:8-oxoG
5-bromoU
5-formyl dU (5-foU)
3,N4-etheno-C (εC) in dsDNA
N3-methyl T (3meT)
8-oxoG
dU in dsDNA
N2,3-etheno-G (N2,3-εG)
8-oxoG from 8-oxoG:T
thymine glycol (Tg)
8-oxoG from 8-oxoG:G
O2-methyl C (O2meC)
T from T:G
1,N6-etheno-A in (1εA) dsDNA
3-ethyl C (3etC)
3,N4-ethano-C (EC)
N7-methyl G (7meG)
hypoxanthine in DNA
uracil glycol (Ug)
3,N4-ethenoC (εC) in ssDNA
2-oxoA
1-methyl G (1meG)
N1-methyl A (1meA)
T→A transversion N3-methylT (3meT) in ssDNA
N3-methyl T (3meT)
T:5-OH-U pair
O4-methyl T (O4meT)
T→C transition N3-methylT (3meT) in ssDNA
thymine glycol (Tg)
N3-methyl T (3meT)
O4-methyl T (O4meT)
T→G transversion
transition 5-formyl dU from 5-formylU:G
M1A (OPA)
5-bromoU
5-formyl dU (5-foU)
M1dG
5-hydroxy-U (5-OH-U)
O6-ethyl G (O6etG)
1,N6-etheno-A (1εA)
N3-methyl T (3meT)
8-methyl G (8meG)
1,N6-ethano A (EA)
dU in dsDNA
N2,3-etheno-G (N2,3-εG)
dU in ssDNA
thymine glycol (Tg)
3-methyl C (3meC)
5-hydroxy-6-hydro-C (5-OH-6-H-C)
O4-methyl T (O4meT)
1,N6-etheno-A in (1εA) dsDNA
3-ethyl C (3etC)
O6-methyl G (O6meG)
5-hydroxy C (5-OH-C)
M1C (OPC)
N3-methylT (3meT) in ssDNA
1,N6-etheno-A (1εA) in ssDNA
A:5-OH-U pair
G:5-OH-U pair
3,N4-ethenoC (εC) in ssDNA
1-methyl G (1meG)
7-methyl A (7meA)
deoxyuridine
cytosine glycol (Cg)
transversion 5-formyl dU from 5-formylU:G
T:5-OH-U pair
5-formyl dU (5-foU)
M1dG
1,N2-etheno-G (1,2εG) in dsDNA
3,N4-etheno-C (εC) in dsDNA
1,N6-etheno-A (1εA)
N3-methyl T (3meT)
8-oxoG
8-methyl G (8meG)
1,N2-etheno-G (εG) in ssDNA
1,N6-ethano A (EA)
3-methyl C (3meC)
O4-methyl T (O4meT)
1,N6-etheno-A in (1εA) dsDNA
3-methyl A (3meA)
3-ethyl C (3etC)
N3-methylT (3meT) in ssDNA
1,N6-etheno-A (1εA) in ssDNA
3,N4-ethenoC (εC) in ssDNA
1-methyl G (1meG)
N1-methyl A (1meA)
3-methyl A (3-meA) in ssDNA