-1 frameshift


OTHER NAME(S):
framing error
reading frame shift
out-of-frame deletion
out-of-frame mutation


DESCRIPTION: A frameshift mutation is a genetic mutation caused by indels (insertions or deletions) of a number of nucleotides that is not evenly divisible by three from a DNA sequence. Due to the triplet nature of gene expression by codons, the insertion or deletion can change the reading frame (the grouping of the codons), resulting in a completely different translation from the original. The earlier in the sequence the deletion or insertion occurs, the more altered the protein produced is.
A frameshift mutation will in general cause the reading of the codons after the mutation to code for different amino acids, but there may be exceptions resulting from the redundancy in the genetic code. Furthermore, the stop codon ("UAA", "UGA" or "UAG") in the original sequence will not be read, and a stop codon could result at an earlier or later site. The protein being created could be abnormally short or abnormally long, and will most likely not be functional.
A frameshift mutation is not the same as a single-nucleotide polymorphism in which a nucleotide is replaced, rather than inserted or deleted.


DNA DAMAGES:
AP-site
1,N2-etheno-G (1,2εG) in dsDNA


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NAME STRUCTURE PROTEINS DNA DAMAGE SOURCE(S) PATHWAY(S) RELATED
AP-site Nfo (endo IV)
APEX1
APEX2
XthA (exo III)
TDP1
UvrC
UvrB
DDB2 (XPE)
unstable adducts
repair intermediate
nucleotide incision repair (NIR)
base excision repair (BER)
nucleotide excision repair (NER)
prokaryotic (SOS) response
1,N2-etheno-G (1,2εG) in dsDNA Mug
ANPG (MPG)
Mug
lipid peroxidation (LPO)
vinyl chloride metabolites
chloroacetaldehyde (CAA)
base excision repair (BER)

Last modification date: Oct. 9, 2011