deletion


OTHER NAME(S):
gene deletion
deficiency
deletion mutation


DESCRIPTION: A deletion is a mutation (a genetic aberration) in which a part of a chromosome or a sequence of DNA is missing. Deletion is the loss of genetic material. Any number of nucleotides can be deleted, from a single base to an entire piece of chromosome. Deletions can be caused by errors in chromosomal crossover during meiosis. This causes several serious genetic diseases. Deletion is also causing frameshift.

DNA DAMAGES:
1,N2-etheno-G (1,2εG) in dsDNA
M1A (OPA)
1,N2-etheno-G (εG) in ssDNA


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NAME STRUCTURE PROTEINS DNA DAMAGE SOURCE(S) PATHWAY(S) RELATED
1,N2-etheno-G (1,2εG) in dsDNA Mug
ANPG (MPG)
Mug
lipid peroxidation (LPO)
vinyl chloride metabolites
chloroacetaldehyde (CAA)
base excision repair (BER)
M1A (OPA) UvrC
UvrB
ERCC5 (XPG)
ERCC4 (XPF)
lipid peroxidation (LPO)
malondialdehyde (MDA)
Fanconi anemia (FA) pathway
nucleotide excision repair (NER)
prokaryotic (SOS) response
1,N2-etheno-G (εG) in ssDNA ALKBH2 lipid peroxidation (LPO)
vinyl chloride metabolites
chloroacetaldehyde (CAA)
direct reversal (DR)

Last modification date: July 3, 2011