transversion


DESCRIPTION: Transversion refers to the substitution of a purine for a pyrimidine or vice versa. It can only be reverted by a spontaneous reversion. Because this type of mutation changes the chemical structure dramatically, the consequences of this change tend to be more drastic than those of transitions. Transversions can be caused by ionizing radiation and alkylating agents.

DNA DAMAGES:
5-formyl dU from 5-formylU:G
T:5-OH-U pair
5-formyl dU (5-foU)
M1dG
1,N2-etheno-G (1,2εG) in dsDNA
3,N4-etheno-C (εC) in dsDNA
1,N6-etheno-A (1εA)
N3-methyl T (3meT)
8-oxoG
8-methyl G (8meG)
1,N2-etheno-G (εG) in ssDNA
1,N6-ethano A (EA)
3-methyl C (3meC)
O4-methyl T (O4meT)
1,N6-etheno-A in (1εA) dsDNA
3-methyl A (3meA)
3-ethyl C (3etC)
N3-methylT (3meT) in ssDNA
1,N6-etheno-A (1εA) in ssDNA
3,N4-ethenoC (εC) in ssDNA
1-methyl G (1meG)
N1-methyl A (1meA)
3-methyl A (3-meA) in ssDNA


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NAME STRUCTURE PROTEINS DNA DAMAGE SOURCE(S) PATHWAY(S) RELATED
5-formyl dU from 5-formylU:G MBD4 (MED1) reactive oxygen species (ROS) base excision repair (BER)
heterochromatin formation
T:5-OH-U pair reactive oxygen species (ROS)
DNA replication errors
ionizing radiation (IR)
5-formyl dU (5-foU) Fpg (MutM)
Mug
SMUG1
AlkA
Nth (endo III)
MBD4 (MED1)
NTHL1
Nei (endo VIII)
NTHL1
reactive oxygen species (ROS) base excision repair (BER)
heterochromatin formation
M1dG UvrC
UvrB
ERCC5 (XPG)
ERCC4 (XPF)
lipid peroxidation (LPO)
reactive oxygen species (ROS)
malondialdehyde (MDA)
Fanconi anemia (FA) pathway
nucleotide excision repair (NER)
prokaryotic (SOS) response
1,N2-etheno-G (1,2εG) in dsDNA Mug
ANPG (MPG)
Mug
lipid peroxidation (LPO)
vinyl chloride metabolites
chloroacetaldehyde (CAA)
base excision repair (BER)
3,N4-etheno-C (εC) in dsDNA Mug
TDG
AlkB
SMUG1
vinyl chloride metabolites
chloroacetaldehyde (CAA)
base excision repair (BER)
direct reversal (DR)
1,N6-etheno-A (1εA) AlkA
Fpg (MutM)
ANPG (MPG)
AlkB
ALKBH2
chloroethylene oxide
lipid peroxidation (LPO)
vinyl chloride metabolites
chloroacetaldehyde (CAA)
base excision repair (BER)
direct reversal (DR)
N3-methyl T (3meT) FTO
AlkB
SN2 methylating agents
methyl methanesulfonate (MMS)
alkylating agents
direct reversal (DR)
8-oxoG Fpg (MutM)
Nei (endo VIII)
hOGG1
NEIL1
UvrC
UvrB
reactive oxygen species (ROS)
ionizing radiation (IR)
base excision repair (BER)
nucleotide excision repair (NER)
prokaryotic (SOS) response
8-methyl G (8meG) AlkA methyl radicals base excision repair (BER)
1,N2-etheno-G (εG) in ssDNA ALKBH2 lipid peroxidation (LPO)
vinyl chloride metabolites
chloroacetaldehyde (CAA)
direct reversal (DR)
1,N6-ethano A (EA) AlkA
ANPG (MPG)
bischloroethyl nitrosourea (BCNU) base excision repair (BER)
3-methyl C (3meC) AlkB
ALKBH2
ALKBH3
ANPG (MPG)
SN2 methylating agents
methyl methanesulfonate (MMS)
methyl chloride
methyl bromide
methyl iodide
alkylating agents
base excision repair (BER)
direct reversal (DR)
O4-methyl T (O4meT) Ogt
Ada
MGMT
SN1 methylating agents
N-methyl-N-nitrosourea (NMU)
alkylating agents
direct reversal (DR)
1,N6-etheno-A in (1εA) dsDNA AlkA
Fpg (MutM)
ANPG (MPG)
AlkB
chloroethylene oxide
lipid peroxidation (LPO)
vinyl chloride metabolites
chloroacetaldehyde (CAA)
base excision repair (BER)
direct reversal (DR)
3-methyl A (3meA) AlkA
Tag
ANPG (MPG)
N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)
SN1 methylating agents
SN2 methylating agents
N-methyl-N-nitrosourea (NMU)
methyl methanesulfonate (MMS)
alkylating agents
base excision repair (BER)
3-ethyl C (3etC) AlkB ethyl methanesulfonate (EMS)
N-ethyl-N-nitrosourea (ENU)
alkylating agents
direct reversal (DR)
N3-methylT (3meT) in ssDNA FTO
AlkB
SN2 methylating agents
methyl methanesulfonate (MMS)
alkylating agents
direct reversal (DR)
1,N6-etheno-A (1εA) in ssDNA ALKBH2 chloroethylene oxide
lipid peroxidation (LPO)
vinyl chloride metabolites
chloroacetaldehyde (CAA)
direct reversal (DR)
3,N4-ethenoC (εC) in ssDNA ALKBH2 reactive oxygen species (ROS)
vinyl chloride metabolites
chloroacetaldehyde (CAA)
direct reversal (DR)
1-methyl G (1meG) AlkB
ANPG (MPG)
methyl methanesulfonate (MMS)
alkylating agents
base excision repair (BER)
direct reversal (DR)
N1-methyl A (1meA) ALKBH3
AlkB
ALKBH2
ANPG (MPG)
SN2 methylating agents
methyl methanesulfonate (MMS)
methyl chloride
methyl bromide
methyl iodide
alkylating agents
base excision repair (BER)
direct reversal (DR)
3-methyl A (3-meA) in ssDNA AlkA N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)
SN1 methylating agents
SN2 methylating agents
N-methyl-N-nitrosourea (NMU)
methyl methanesulfonate (MMS)
alkylating agents
streptozotocin
base excision repair (BER)

Last modification date: July 3, 2011