AP-site


OTHER NAME(S):
apurinic/apyrimidinic site


ABBREVIATIONS:
AP


DESCRIPTION: AP sites can be formed by spontaneous depurination, but also occur as intermediates in base excision repair. In this process, a DNA glycosylase recognizes a damaged base and cleaves the N-glycosidic bond to release the base, leaving an AP site.
An AP site (apurinic/apyrimidinic site), also known as an abasic site, is a location in DNA that has neither a purine nor a pyrimidine base, usually due to DNA damage.

DNA DAMAGES:
N7-methyl G (7meG)
aflatoxin-G
3-methyl A (3meA)
deoxyuridine
3-methyl A (3-meA) in ssDNA


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NAME STRUCTURE PROTEINS DNA DAMAGE SOURCE(S) PATHWAY(S) RELATED
N7-methyl G (7meG) AlkA
Fpg (MutM)
Tag
ANPG (MPG)
N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)
SN1 methylating agents
SN2 methylating agents
methyl methanesulfonate (MMS)
alkylating agents
base excision repair (BER)
aflatoxin-G UvrC
UvrB
ERCC5 (XPG)
ERCC4 (XPF)
aflatoxin Fanconi anemia (FA) pathway
nucleotide excision repair (NER)
prokaryotic (SOS) response
3-methyl A (3meA) AlkA
Tag
ANPG (MPG)
N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)
SN1 methylating agents
SN2 methylating agents
N-methyl-N-nitrosourea (NMU)
methyl methanesulfonate (MMS)
alkylating agents
base excision repair (BER)
deoxyuridine Ung
Mug
TDG
SMUG1
UNG
spontaneous deamination base excision repair (BER)
3-methyl A (3-meA) in ssDNA AlkA N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)
SN1 methylating agents
SN2 methylating agents
N-methyl-N-nitrosourea (NMU)
methyl methanesulfonate (MMS)
alkylating agents
streptozotocin
base excision repair (BER)

Last modification date: Aug. 14, 2011