cell cycle arrest


OTHER NAME(S):
cell cycle inhibition


DESCRIPTION: The cell cycle, or cell-division cycle, is the series of events that takes place in a cell leading to its division and duplication (replication). In cells without a nucleus (prokaryotic), the cell cycle occurs via a process termed binary fission. In cells with a nucleus (eukaryotes), the cell cycle can be divided in two brief periods: interphase—during which the cell grows, accumulating nutrients needed for mitosis and duplicating its DNA—and the mitosis (M) phase, during which the cell splits itself into two distinct cells, often called "daughter cells".
Some inhibitors and environmental agents can halt cell cycle.

DNA DAMAGES:
5'-AMP end
5-bromoU
5-fluoroU from 5-fluoroU:G
5-fluoroU from 5-fluoroU:A
3-methyl A (3meA)
3,N4-alpha-OH-gamma-methyl-propano-C (mHPC)
DNA-psoralen
3'-OH end
p-BQ-G
1,N6-alpha-hydroxyethano-A (HEA)
5'-P end
5'-TOP2 termini
N3-methylT (3meT) in ssDNA
3'-P
1,N6-ethano A (EA)
1,N2-propano-G (PG)
p-BQ-C
intErstrand crosslinks (ICLs)
5-fluoro-dU
3-methyl A (3-meA) in ssDNA
intrAstrand crosslink


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NAME STRUCTURE PROTEINS DNA DAMAGE SOURCE(S) PATHWAY(S) RELATED
5'-AMP end APTX abortive DNA ligation
repair intermediate
5-bromoU TDG cancer chemotherapy
methyl bromide
base excision repair (BER)
5-fluoroU from 5-fluoroU:G MBD4 (MED1) cancer chemotherapy base excision repair (BER)
heterochromatin formation
5-fluoroU from 5-fluoroU:A SMUG1 cancer chemotherapy base excision repair (BER)
3-methyl A (3meA) AlkA
Tag
ANPG (MPG)
N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)
SN1 methylating agents
SN2 methylating agents
N-methyl-N-nitrosourea (NMU)
methyl methanesulfonate (MMS)
alkylating agents
base excision repair (BER)
3,N4-alpha-OH-gamma-methyl-propano-C (mHPC) Mug crotonaldehyde (CRA)
lipid peroxidation (LPO)
base excision repair (BER)
DNA-psoralen UvrC
UvrB
NEIL1
psoralen base excision repair (BER)
nucleotide excision repair (NER)
prokaryotic (SOS) response
3'-OH end XthA (exo III)
Nfo (endo IV)
APEX1
APEX2
DnaQ
TREX2
TREX1 (DNase III)
repair intermediate DNA replication
base excision repair (BER)
mismatch repair (MMR)
homologous recombination (HR)
Fanconi anemia (FA) pathway
nucleotide incision repair (NIR)
p-BQ-G UvrC
UvrB
ERCC5 (XPG)
ERCC4 (XPF)
benzene Fanconi anemia (FA) pathway
nucleotide excision repair (NER)
prokaryotic (SOS) response
1,N6-alpha-hydroxyethano-A (HEA) lipid peroxidation (LPO)
vinyl chloride metabolites
chloroacetaldehyde (CAA)
5'-P end RecJ
FEN1 (DNase IV)
DNA Pol I
repair intermediate DNA replication
base excision repair (BER)
nucleotide excision repair (NER)
mismatch repair (MMR)
homologous recombination (HR)
non-homologous end-joining (NHEJ)
5'-TOP2 termini TDP2 cancer chemotherapy
repair intermediate
N3-methylT (3meT) in ssDNA FTO
AlkB
SN2 methylating agents
methyl methanesulfonate (MMS)
alkylating agents
direct reversal (DR)
3'-P APTX
APEX1
XthA (exo III)
Nfo (endo IV)
APEX2
PNKP (PNK)
repair intermediate nucleotide incision repair (NIR)
base excision repair (BER)
1,N6-ethano A (EA) AlkA
ANPG (MPG)
bischloroethyl nitrosourea (BCNU) base excision repair (BER)
1,N2-propano-G (PG) lipid peroxidation (LPO)
p-BQ-C UvrC
UvrB
ERCC5 (XPG)
ERCC4 (XPF)
benzene Fanconi anemia (FA) pathway
nucleotide excision repair (NER)
prokaryotic (SOS) response
intErstrand crosslinks (ICLs) UvrC
UvrB
ERCC5 (XPG)
ERCC4 (XPF)
MUS81
EME1
ERCC1
SLX4
SLX1A
SLX1B
TOP3A
bischloroethyl nitrosourea (BCNU)
mitomycin C
psoralen
cisplatin
nitrogen mustard
cancer chemotherapy
acrolein (ACR)
crotonaldehyde (CRA)
trans-4-hydroxy-2-nonenal (HNE)
Fanconi anemia (FA) pathway
nucleotide excision repair (NER)
prokaryotic (SOS) response
homologous recombination (HR)
DNA replication
5-fluoro-dU UNG
TDG
MBD4 (MED1)
SMUG1
cancer chemotherapy base excision repair (BER)
heterochromatin formation
3-methyl A (3-meA) in ssDNA AlkA N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)
SN1 methylating agents
SN2 methylating agents
N-methyl-N-nitrosourea (NMU)
methyl methanesulfonate (MMS)
alkylating agents
streptozotocin
base excision repair (BER)
intrAstrand crosslink UvrC
UvrB
ERCC5 (XPG)
ERCC4 (XPF)
mitomycin C
psoralen
cisplatin
cancer chemotherapy
nitrogen mustard
Fanconi anemia (FA) pathway
nucleotide excision repair (NER)
prokaryotic (SOS) response

Last modification date: July 3, 2011