5-OH-meU in ssDNA

FULL NAME: 5-hydroxymethyl U from ssDNA


DESCRIPTION:
Oxidation of the methyl group of thymine yields 5-(hydroxymethyl)uracil (5-hmU). A primary alcohol that is uracil bearing a hydroxymethyl substituent at the 5-position.

DAMAGE TYPE: hydrate


DNA DAMAGE SOURCE(S) (MAIN):
reactive oxygen species (ROS)
ionizing radiation (IR)


DNA DAMAGE EFFECT(S) (MAIN):
mutagenesis


PATHWAYS:
base excision repair (BER)
heterochromatin formation


DNA repair protein(s) related to damage:
SMUG1
MBD4 (MED1)


Last modification date: Oct. 10, 2011