8-oxoG

FULL NAME: 8-oxo-guanine


DESCRIPTION:
8-Oxoguanine (8-hydroxyguanine, 8-oxo-Gua, or OH8Gua) is one of the most common DNA lesions resulting from reactive oxygen species (ROS) and can result in a mismatched pairing with adenine resulting in G to T and C to A substitutions in the genome. In humans, it is primarily repaired by the DNA glycosylase OGG1. 8-Oxoguanine can be removed from DNA by the protein products of the E. coli mutM and mutY genes. The MutM protein removes 8-oxoguanine (and other oxidized bases), while the MutY protein removes adenine that is mispaired to 8-oxoguanine. 8-oxo can be caused by ionizing radiation, in connection with oxidative metabolism.

DAMAGE TYPE: oxidative damage


DNA DAMAGE SOURCE(S) (MAIN):
reactive oxygen species (ROS)
ionizing radiation (IR)


DNA DAMAGE EFFECT(S) (MAIN):
C→A transversion
G→T transversion
mutagenesis
point mutation
substitution
transversion


DNA DAMAGE EFFECT(S) (MINOR):
no mutagenesis


PATHWAYS:
base excision repair (BER)
nucleotide excision repair (NER)
prokaryotic (SOS) response


DNA repair protein(s) related to damage:
Fpg (MutM)
Nei (endo VIII)
hOGG1
NEIL1
UvrC
UvrB


Last modification date: Oct. 9, 2011