5-fluoro-dU

FULL NAME: 5-fluorouracil 2'-deoxyriboside


DESCRIPTION:
A fluorouracil nucleoside derivatives, the body directly into a 5-deoxy - uridine fluoride acid, which inhibited DNA synthesis. Antineoplastic agents, and the mechanism of 5-fluorouracil same can block DNA synthesis inhibition of tumor cell growth, and fluoride in urine, pyrimidine, its high efficacy and low toxicity. Shuai applicable to the treatment : cancer, to colon cancer, colon cancer, breast cancer, liver cancer, etc.. Right inoperable primary liver cancer significantly. Hepatic arterial cannulation in effect was better. Preparations are capsule, powder. Side effects of bone marrow suppression, gastrointestinal tract and skin response to local reactions and liver function.

DAMAGE TYPE: OTHER


DNA DAMAGE SOURCE(S) (MAIN):
cancer chemotherapy


DNA DAMAGE EFFECT(S) (MAIN):
cell cycle arrest
cytotoxic
stalled replication fork


PATHWAYS:
base excision repair (BER)
heterochromatin formation


DNA repair protein(s) related to damage:
UNG
TDG
MBD4 (MED1)
SMUG1


Last modification date: Oct. 9, 2011