5-hydroxy C (5-OH-C)

FULL NAME: 5-hydroxycytosine


DESCRIPTION:
The most common base substitution arising from oxidative damage of DNA is a GC ā†’ AT transition. The oxidized lesions that give rise to this mutation are three oxidized cytosines, 5-hydroxycytosine, 5-hydroxyuracil, and uracil glycol. 5-OH-Cyt appears to be more mutagenic than any other product of oxidative DNA damage.

DAMAGE TYPE: hydrate


DNA DAMAGE SOURCE(S) (MAIN):
reactive oxygen species (ROS)
ionizing radiation (IR)


DNA DAMAGE SOURCE(S) (MINOR):
ionizing radiation (IR)


DNA DAMAGE EFFECT(S) (MAIN):
Cā†’T transition
transition


PATHWAYS:
base excision repair (BER)


DNA repair protein(s) related to damage:
Nth (endo III)
Fpg (MutM)
Mug
Nei (endo VIII)
NEIL1
NEIL2
NTHL1


Last modification date: Oct. 9, 2011